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基于柠檬酸盐的贻贝启发型镁白磷钙石复合黏合剂增强了骨腱愈合。

Citrate-based mussel-inspired magnesium whitlockite composite adhesives augmented bone-to-tendon healing.

机构信息

Department of Orthopedics; Department of Pediatric Orthopedics, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

Department of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.

出版信息

J Mater Chem B. 2021 Oct 13;9(39):8202-8210. doi: 10.1039/d1tb01710a.

Abstract

Citrate-based mussel-inspired whitlockite composite adhesives (CMWAs) were developed and administered to the bone-tendon interface in anterior cruciate ligament (ACL) reconstruction. CMWAs could improve the initial bone-tendon bonding strength, promote the bony inward growth from the bone tunnel and enhance the chondrogenesis and osteogenesis of the bone-tendon interface, thus augmenting bone-to-tendon healing.

摘要

基于柠檬酸盐的贻贝启发的磷酸钙复合黏合剂(CMWAs)被开发并应用于前交叉韧带(ACL)重建中的骨-腱界面。CMWAs 可以提高初始骨-腱结合强度,促进骨隧道内的骨质向内生长,并增强骨-腱界面的软骨生成和骨生成,从而增强骨-腱愈合。

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