Emeritus Professor of Pediatrics, University of Pennsylvania, Vaxconsult, Doylestown, Pennsylvania, USA.
J Infect Dis. 2021 Sep 30;224(12 Suppl 2):S360-S366. doi: 10.1093/infdis/jiaa530.
Rubella virus is the most teratogenic virus known to science and is capable of causing large epidemics. The RA 27/3 rubella vaccine, usually combined with measles vaccine, has eliminated rubella and congenital rubella syndrome from much of the world, notably from the Western Hemisphere. Except in immunosuppressed individuals, it is remarkably safe. Together with rubella vaccine strains used in China and Japan, eradication of the rubella virus is possible, indeed more feasible than eradication of measles or mumps.
风疹病毒是目前科学界已知的致畸性最强的病毒,能够引发大规模的流行。风疹病毒 RA 27/3 减毒活疫苗,通常与麻疹疫苗联合使用,已经在世界上许多地方消除了风疹和先天性风疹综合征,尤其是在西半球。除了免疫抑制个体外,该疫苗的安全性非常高。结合中国和日本使用的风疹疫苗株,风疹病毒的根除是可能的,事实上比麻疹或腮腺炎的根除更可行。