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迈向消除风疹的进展 - 西太平洋区域,2000-2019 年。

Progress Toward Rubella Elimination - Western Pacific Region, 2000-2019.

出版信息

MMWR Morb Mortal Wkly Rep. 2020 Jun 19;69(24):744-750. doi: 10.15585/mmwr.mm6924a4.

Abstract

Rubella is the leading vaccine-preventable cause of birth defects. Rubella typically manifests as a mild febrile rash illness; however, infection during pregnancy, particularly during the first trimester, can result in miscarriage, fetal death, or a constellation of malformations known as congenital rubella syndrome (CRS), commonly including one or more visual, auditory, or cardiac defects (1). In 2012, the Regional Committee of the World Health Organization (WHO) Western Pacific Region (WPR)* committed to accelerate rubella control, and in 2017, resolved that all countries or areas (countries) in WPR should aim for rubella elimination as soon as possible (2,3). WPR countries are capitalizing on measles elimination activities, using a combined measles and rubella vaccine, case-based surveillance for febrile rash illness, and integrated diagnostic testing for measles and rubella. This report summarizes progress toward rubella elimination and CRS prevention in WPR during 2000-2019. Coverage with a first dose of rubella-containing vaccine (RCV1) increased from 11% in 2000 to 96% in 2019. During 1970-2019, approximately 84 million persons were vaccinated through 62 supplementary immunization activities (SIAs) conducted in 27 countries. Reported rubella incidence increased from 35.5 to 71.3 cases per million population among reporting countries during 2000-2008, decreased to 2.1 in 2017, and then increased to 18.4 in 2019 as a result of outbreaks in China and Japan. Strong sustainable immunization programs, closing of existing immunity gaps, and maintenance of high-quality surveillance to respond rapidly to and contain outbreaks are needed in every WPR country to achieve rubella elimination in the region.

摘要

风疹是可通过疫苗预防的主要出生缺陷病因。风疹通常表现为轻度发热出疹性疾病;然而,妊娠期间感染(特别是妊娠早期)可导致流产、死胎,或出现先天性风疹综合征(CRS)的一系列畸形,通常包括一种或多种视觉、听觉或心脏缺陷(1)。2012 年,世界卫生组织(世卫组织)西太平洋区域(WPR)区域委员会*承诺加快风疹控制工作,并于 2017 年决定,WPR 所有国家或地区(国家)应尽快实现消除风疹(2,3)。WPR 国家正在利用麻疹消除活动,使用麻疹-风疹联合疫苗、发热出疹性疾病病例监测以及麻疹和风疹综合诊断检测。本报告总结了 2000-2019 年期间 WPR 消除风疹和预防 CRS 的进展情况。风疹含细胞培养疫苗(RCV1)首剂接种覆盖率从 2000 年的 11%增加到 2019 年的 96%。在 1970-2019 年期间,27 个国家通过 62 次补充免疫活动(SIAs)为大约 8400 万人接种了疫苗。在 2000-2008 年期间,报告发病国家的风疹报告发病率从每百万人 35.5 例增至 71.3 例,2017 年降至 2.1 例,2019 年因中国和日本暴发疫情又增至 18.4 例。WPR 每个国家都需要有强有力的可持续免疫规划、消除现有的免疫差距以及保持高质量监测,以便快速应对和控制疫情暴发,从而在该区域实现消除风疹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f3/7302473/0ba945cdfec9/mm6924a4-F.jpg

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