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Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?

作者信息

Hassan Venkatesh Goutham, Abou Khouzam Raefa, Shaaban Moustafa Elsayed Walid, Ahmed Zeinelabdin Nagwa, Terry Stéphane, Chouaib Salem

机构信息

Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates.

College of Dentistry, Gulf Medical University, Ajman, United Arab Emirates.

出版信息

Oncoimmunology. 2021 Sep 27;10(1):1974233. doi: 10.1080/2162402X.2021.1974233. eCollection 2021.

DOI:10.1080/2162402X.2021.1974233
PMID:34595058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8477925/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13a3/8477925/2b6d075a84db/KONI_A_1974233_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13a3/8477925/2b6d075a84db/KONI_A_1974233_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13a3/8477925/2b6d075a84db/KONI_A_1974233_F0001_OC.jpg

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本文引用的文献

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Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity.周期性缺氧诱导的复制灾难导致 APOBEC3B 活性增加。
Nucleic Acids Res. 2021 Jul 21;49(13):7492-7506. doi: 10.1093/nar/gkab551.
2
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy.靶向 HIF-1α转录活性可促使细胞毒性免疫效应细胞浸润黑色素瘤并改善联合免疫治疗。
Oncogene. 2021 Jul;40(28):4725-4735. doi: 10.1038/s41388-021-01846-x. Epub 2021 Jun 21.
3
An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment.
利用纳米颗粒靶向乳腺肿瘤细胞外基质和基质
Clin Transl Oncol. 2024 Dec 18. doi: 10.1007/s12094-024-03793-x.
4
Artificial blood-hope and the challenges to combat tumor hypoxia for anti-cancer therapy.人造血液——对抗肿瘤缺氧以进行抗癌治疗的希望与挑战。
Med Biol Eng Comput. 2025 Apr;63(4):933-957. doi: 10.1007/s11517-024-03233-6. Epub 2024 Nov 30.
5
Trial watch: anticancer vaccination with dendritic cells.试验观察：树突状细胞抗癌疫苗。
Oncoimmunology. 2024 Oct 9;13(1):2412876. doi: 10.1080/2162402X.2024.2412876. eCollection 2024.
6
Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy.血红素加氧酶-1 与前列腺癌：功能、调控及其在癌症治疗中的意义。
Int J Mol Sci. 2024 Aug 24;25(17):9195. doi: 10.3390/ijms25179195.
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Immune checkpoint inhibitors in bone metastasis: Clinical challenges, toxicities, and mechanisms.骨转移中的免疫检查点抑制剂：临床挑战、毒性及机制
J Bone Oncol. 2023 Sep 30;43:100505. doi: 10.1016/j.jbo.2023.100505. eCollection 2023 Dec.
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Front Cell Dev Biol. 2023 Mar 9;11:1095419. doi: 10.3389/fcell.2023.1095419. eCollection 2023.
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Cancers (Basel). 2023 Feb 15;15(4):1235. doi: 10.3390/cancers15041235.
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World J Surg Oncol. 2021 Apr 17;19(1):123. doi: 10.1186/s12957-021-02204-7.
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Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy.细胞代谢与DNA修复途径：对癌症治疗的启示
Front Cell Dev Biol. 2021 Mar 23;9:633305. doi: 10.3389/fcell.2021.633305. eCollection 2021.
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Front Oncol. 2021 Feb 22;11:616722. doi: 10.3389/fonc.2021.616722. eCollection 2021.