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经颅直流电刺激(tDCS)增强记忆。

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement.

机构信息

Institute for Medical Research, Human Neuroscience Group, University of Belgrade;

Faculty of Philosophy, Institute of Psychology, University of Belgrade.

出版信息

J Vis Exp. 2021 Sep 18(175). doi: 10.3791/62681.


DOI:10.3791/62681
PMID:34605816
Abstract

Memory enhancement is one of the great challenges in cognitive neuroscience and neurorehabilitation. Among various techniques used for memory enhancement, transcranial direct current stimulation (tDCS) is emerging as an especially promising tool for improvement of memory functions in a non-invasive manner. Here, we present a tDCS protocol that can be applied for memory enhancement in healthy-participant studies as well as in aging and dementia research. The protocol uses weak constant anodal current to stimulate cortical targets within cortico-hippocampal functional network engaged in memory processes. The target electrode is placed either on the posterior parietal cortex (PPC) or the dorsolateral prefrontal cortex (DLPFC), while the return electrode is placed extracranially (i.e., on the contralateral cheek). In addition, we outline a more advanced method of oscillatory tDCS, mimicking a natural brain rhythm to promote hippocampus-dependent memory functions, which can be applied in a personalized and non-personalized manner. We present illustrative results of associative and working memory improvement following single tDCS sessions (20 minutes) in which the described electrode montages were used with current intensities between 1.5 mA and 1.8 mA. Finally, we discuss crucial steps in the protocol and methodological decisions that must be made when designing a tDCS study on memory.

摘要

记忆增强是认知神经科学和神经康复领域的重大挑战之一。在用于增强记忆的各种技术中,经颅直流电刺激(tDCS)作为一种非侵入性的方法,正在成为改善记忆功能的一种很有前途的工具。在这里,我们提出了一种 tDCS 方案,可用于健康参与者研究以及衰老和痴呆症研究中的记忆增强。该方案使用弱恒定阳极电流刺激参与记忆过程的皮质 - 海马功能网络内的皮质靶标。目标电极放置在后顶叶皮层(PPC)或背外侧前额叶皮层(DLPFC)上,而返回电极放置在颅外(即对侧脸颊上)。此外,我们概述了一种更先进的振荡 tDCS 方法,模拟自然脑节律以促进海马依赖的记忆功能,可采用个性化和非个性化方式应用。我们展示了单次 tDCS 治疗(20 分钟)后联想和工作记忆改善的说明性结果,其中使用了描述的电极布局和 1.5 mA 至 1.8 mA 的电流强度。最后,我们讨论了方案中的关键步骤和在设计记忆的 tDCS 研究时必须做出的方法学决策。

相似文献

[1]
Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement.

J Vis Exp. 2021-9-18

[2]
The effects of offline and online prefrontal vs parietal transcranial direct current stimulation (tDCS) on verbal and spatial working memory.

Neurobiol Learn Mem. 2021-3

[3]
Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects.

Brain Stimul. 2018-6-18

[4]
Differential effects of high-definition transcranial direct current stimulation on verbal working memory performance according to sensory modality.

Neurosci Lett. 2018-11-20

[5]
Testing assumptions on prefrontal transcranial direct current stimulation: Comparison of electrode montages using multimodal fMRI.

Brain Stimul. 2018-5-4

[6]
Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory.

Neurobiol Learn Mem. 2018-12-13

[7]
Exploring the effects of Transcranial Direct Current Stimulation over the prefrontal cortex on working memory: A cluster analysis approach.

Behav Brain Res. 2019-8-6

[8]
No effect of transcranial direct current stimulation of the dorsolateral prefrontal cortex on short-term memory.

CNS Neurosci Ther. 2017-11-23

[9]
Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: A resting-state EEG and TMS-EEG study.

Brain Stimul. 2018-6-18

[10]
Transcranial random noise stimulation is more effective than transcranial direct current stimulation for enhancing working memory in healthy individuals: Behavioural and electrophysiological evidence.

Brain Stimul. 2020

引用本文的文献

[1]
Memory dependent modulation of hippocampal theta power through frontoparietal phase synchronous brain stimulation.

Sci Rep. 2025-7-21

[2]
Combined therapy with contralateral controlled functional electrical stimulation and transcranial direct current stimulation for early post-stroke hand dysfunction.

Biomed Eng Online. 2025-7-4

[3]
Computational insights into magnetoelectric nanoparticles for neural stimulation.

Front Neurosci. 2025-4-28

[4]
Multi-session tDCS over the posterior parietal cortex and associative memory.

PLoS One. 2025-1-30

[5]
Transcranial Electrical Stimulation for Associative Memory Enhancement: State-of-the-Art from Basic to Clinical Research.

Life (Basel). 2023-5-2

[6]
Efficacy of Unilateral and Bilateral Parietal Transcranial Direct Current Stimulation on Right Hemispheric Stroke Patients With Neglect Symptoms: A Proof-of-Principle Study.

Brain Neurorehabil. 2022-5-4

[7]
Effects of online parietal transcranial electric stimulation on associative memory: a direct comparison between tDCS, theta tACS, and theta-oscillatory tDCS.

Sci Rep. 2022-8-18

[8]
Efficacy and Safety of Transcranial Electric Stimulation during the Perinatal Period: A Systematic Literature Review and Three Case Reports.

J Clin Med. 2022-7-13

[9]
Inter-Individual Variability in tDCS Effects: A Narrative Review on the Contribution of Stable, Variable, and Contextual Factors.

Brain Sci. 2022-4-20

[10]
Understanding the Effects of Transcranial Electrical Stimulation in Numerical Cognition: A Systematic Review for Clinical Translation.

J Clin Med. 2022-4-7

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