Brand A, van Leeuwen A, Eernisse J G, van Rood J J
Blood. 1978 May;51(5):781-8.
Although the value of HLA matching for the selection of platelet donors for patients refractory to random platelets is beyond doubt, even perfectly matched combinations sometimes fail to give a satisfactory transfusion response. With HLA typing and negative lymphocytotoxicity crossmatches, 35% of the platelet transfusions administered to 15 patients gave disappointing results (29 of 82). Additional crossmatching with the newly developed platelet fluorescence test described in this paper reduced the unexpected transfusion failures to 7% (6 of 82). Five of these failures were observed in one patient. The target of the antibodies detected with this platelet fluorescence test is not yet fully specified. It seems probable that both HLA and platelet-specific non-HLA antibodies were detected. No correlation of the results of platelet transfusions with the presence or absence of leukoagglutinating antibodies was found.
尽管对于随机血小板输注无效的患者而言，通过人类白细胞抗原（HLA）配型来选择血小板供体的价值毋庸置疑，但即便完全匹配的组合有时也无法产生令人满意的输血反应。在对15例患者进行HLA分型和阴性淋巴细胞毒性交叉配型后，82次血小板输注中有29次（35%）结果令人失望。采用本文所述新开发的血小板荧光试验进行额外交叉配型后，意外输血失败率降至7%（82次中有6次）。其中5次失败出现在1例患者身上。通过这种血小板荧光试验检测到的抗体靶点尚未完全明确。似乎检测到的既有HLA抗体，也有血小板特异性非HLA抗体。未发现血小板输注结果与是否存在白细胞凝集抗体之间存在相关性。
