Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Japan.
J Diabetes Investig. 2022 Mar;13(3):453-459. doi: 10.1111/jdi.13692. Epub 2021 Oct 23.
AIM/INTRODUCTION: As the association between a fasting glucose concentration of 90-99 mg/dL and the onset of type 2 diabetes is still controversial, we aimed to assess it in 37,148 Japanese individuals with a normal plasma glucose concentration.
This long-term retrospective cohort study included individuals having a medical checkup at Panasonic Corporation from 2008 to 2018. In total, 1,028 participants developed type 2 diabetes.
Cox regression analyses revealed that the risk for the onset of diabetes increased by 9.0% per 1 mg/dL increase in fasting plasma glucose concentration in subjects with the concentration ranging from 90 to 99 mg/dL. Compared with individuals with a fasting glucose concentration of ≤89 mg/dL, the adjusted hazard ratios for developing diabetes were 1.53 (95% CI; 1.22-1.91), 1.76 (95% CI; 1.41-2.18), 1.89 (95% CI; 1.52-2.35), 3.17 (95% CI; 2.61-3.84), and 3.41 (95% CI; 2.79-4.15) at fasting plasma glucose concentrations of 90-91, 92-93, 94-95, 96-97, and 98-99 mg/dL, respectively. In populations with obesity, the adjusted hazards ratios for developing diabetes were 1.56 (95% CI; 1.15-2.09), 1.82 (95% CI; 1.37-2.40), 2.05 (95% CI; 1.55-2.69), 3.53 (95% CI; 2.79-4.46), and 3.28 (95% CI; 2.53-4.22) at fasting plasma glucose concentrations of 90-91, 92-93, 94-95, 96-97, and 98-99 mg/dL, respectively.
This study demonstrates that the risk of type 2 diabetes among subjects having a fasting plasma glucose concentration of 90-99 mg/dL, is progressively higher with an increasing level of fasting plasma glucose concentration in a Japanese people.
目的/引言：由于空腹血糖浓度为 90-99mg/dL 与 2 型糖尿病发病之间的关联仍存在争议，我们旨在评估 37148 名空腹血糖正常的日本个体。
这项长期回顾性队列研究纳入了 2008 年至 2018 年在松下公司接受体检的个体。共有 1028 名参与者患上了 2 型糖尿病。
Cox 回归分析显示，空腹血浆葡萄糖浓度在 90-99mg/dL 范围内的受试者，空腹血浆葡萄糖浓度每增加 1mg/dL，糖尿病发病风险增加 9.0%。与空腹血糖浓度≤89mg/dL 的个体相比，空腹血糖浓度为 90-91mg/dL、92-93mg/dL、94-95mg/dL、96-97mg/dL 和 98-99mg/dL 的个体发生糖尿病的调整后危险比分别为 1.53（95%CI；1.22-1.91）、1.76（95%CI；1.41-2.18）、1.89（95%CI；1.52-2.35）、3.17（95%CI；2.61-3.84）和 3.41（95%CI；2.79-4.15）。在肥胖人群中，空腹血糖浓度为 90-91mg/dL、92-93mg/dL、94-95mg/dL、96-97mg/dL 和 98-99mg/dL 的个体发生糖尿病的调整后危险比分别为 1.56（95%CI；1.15-2.09）、1.82（95%CI；1.37-2.40）、2.05（95%CI；1.55-2.69）、3.53（95%CI；2.79-4.46）和 3.28（95%CI；2.53-4.22）。
本研究表明，在空腹血糖浓度为 90-99mg/dL 的日本人群中，随着空腹血糖浓度的升高，2 型糖尿病的发病风险逐渐升高。
