利用行波离子淌度质谱分析蛋白-糖胺聚糖相互作用。
Analysis of Protein-Glycosaminoglycan Interactions Using Traveling Wave Ion-Mobility Mass Spectrometry.
机构信息
Department of Chemistry, University of Georgia, Athens, GA, USA.
出版信息
Methods Mol Biol. 2022;2303:87-92. doi: 10.1007/978-1-0716-1398-6_8.
PMID:34626372
Abstract
Traveling wave ion-mobility mass spectrometry (TWIMS) combined with native mass spectrometry (MS) has emerged as a powerful tool for analyzing biomolecules, including complexes of protein and heparan sulfate (HS). This technique allows determination of the stoichiometry of the protein-HS interaction and information on the overall 3D molecular envelope.
摘要
traveling wave 离子淌度质谱（TWIMS）与 native 质谱（MS）相结合，已成为分析生物分子（包括蛋白质和肝素硫酸盐（HS）复合物）的强大工具。该技术可确定蛋白质-HS 相互作用的化学计量比以及整体 3D 分子包络的信息。
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