Webster Linzi Arndt, Villalobos Alexander, Majdalany Bill S, Bercu Zachary L, Gandhi Ripal T, Kokabi Nima
Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Miami Cardiac and Vascular Institute, Miami Cancer Institute, Miami, FL.
Semin Intervent Radiol. 2021 Oct;38(4):405-411. doi: 10.1055/s-0041-1732323. Epub 2021 Oct 7.
Thoughtful and accurate dosimetry is critical to obtain the safest and most efficacious yttrium-90 (Y90) radioembolization of primary and secondary liver cancers. Three dosimetry models are currently used in clinical practice, namely, body surface area model, medical internal radiation dose model, and the partition model. The objective of this review is to briefly outline the history behind Y90 dosimetry and the difference between the aforementioned models. When applying these three models to a single case, the differences between them are further demonstrated. Each dosimetry model in clinical practice has its own benefits and limitations. Therefore, it is incumbent upon practicing interventional radiologists to be aware of these differences to optimize treatment outcomes for their patients.
精确且周全的剂量测定对于实现原发性和继发性肝癌最安全、有效的钇-90（Y90）放射性栓塞治疗至关重要。目前临床实践中使用三种剂量测定模型，即体表面积模型、医学内照射剂量模型和分区模型。本综述的目的是简要概述Y90剂量测定背后的历史以及上述模型之间的差异。将这三种模型应用于单个病例时，它们之间的差异会进一步显现。临床实践中的每种剂量测定模型都有其自身的优点和局限性。因此，执业介入放射科医生有责任了解这些差异，以便为患者优化治疗效果。
