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用于原位肝细胞癌动脉介入化疗-光热治疗的生物相容性硫化铜基纳米复合材料。

Biocompatible copper sulfide-based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma.

作者信息

Li X, Yuan H J, Tian X M, Tang J, Liu L F, Liu F Y

机构信息

Department of Interventional Radiology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, PR China.

Department of Gerontology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, PR China.

出版信息

Mater Today Bio. 2021 Aug 25;12:100128. doi: 10.1016/j.mtbio.2021.100128. eCollection 2021 Sep.

DOI:10.1016/j.mtbio.2021.100128
PMID:34632360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8487074/
Abstract

Transcatheter arterial embolization has been considered as a promising targeted delivery approach for hepatocellular carcinoma (HCC). Currently, chemoembolization was the main treatment for unresectable HCC. However, the traditional chemoembolization treatment suffers from undesirable therapeutic effects and serious side-effects. In this study, the doxorubicin (DOX)-encapsulated and near-infrared (NIR)-responsible copper sulfide (CuS)-based nanotherapeutics was developed for magnetic resonance imaging (MRI)-guided chemo-photothermal therapy of HCC tumor in rats. The DOX-loaded CuS nanocomposites (DOX@BSA-CuS) demonstrated distinct NIR-triggered drug release behavior and high photothermal effect. In an orthotopic HCC rat model, DOX@BSA-CuS nanocomposites were selectively delivered to the tumor site the intra-arterial transcatheter. The proposed DOX@BSA-CuS nanocomposites plus NIR laser irradiation exhibited significant tumor growth suppression performance. Moreover, the treatment progress can be monitored by MRI images. Finally, the preliminary toxicity estimate suggested the negligible side-effect of DOX@BSA-CuS nanocomposites during the therapeutic process. These results suggest the clinical translational potential possibility for imaging-guided arterial embolization with DOX@BSA-CuS nanocomposites for the treatment of HCC.

摘要

经导管动脉栓塞术被认为是一种有前景的肝细胞癌（HCC）靶向递送方法。目前，化疗栓塞是不可切除HCC的主要治疗方法。然而，传统的化疗栓塞治疗存在不良治疗效果和严重副作用。在本研究中，开发了用于大鼠HCC肿瘤磁共振成像（MRI）引导下化疗-光热治疗的载有阿霉素（DOX）且对近红外（NIR）有响应的硫化铜（CuS）基纳米治疗剂。载有DOX的CuS纳米复合材料（DOX@BSA-CuS）表现出明显的近红外触发药物释放行为和高光热效应。在原位HCC大鼠模型中，通过动脉内导管将DOX@BSA-CuS纳米复合材料选择性递送至肿瘤部位。所提出的DOX@BSA-CuS纳米复合材料加近红外激光照射表现出显著的肿瘤生长抑制性能。此外，治疗过程可通过MRI图像进行监测。最后，初步毒性评估表明DOX@BSA-CuS纳米复合材料在治疗过程中的副作用可忽略不计。这些结果表明，DOX@BSA-CuS纳米复合材料用于HCC治疗的成像引导动脉栓塞术具有临床转化的潜在可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/888c102ed203/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/da3f5e817353/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/6d91165ed854/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/e7eb89a18737/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/116d7f4e27d3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/ce5d611d3796/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/a3a07fa26d7f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/e315681354b7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/bc9104c81d75/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/7bfb45faed9f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/888c102ed203/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/da3f5e817353/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/6d91165ed854/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/e7eb89a18737/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/116d7f4e27d3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/ce5d611d3796/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/a3a07fa26d7f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/e315681354b7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/bc9104c81d75/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/7bfb45faed9f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974d/8487074/888c102ed203/gr8.jpg

相似文献

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Biocompatible copper sulfide-based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma.

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引用本文的文献

[1]
Recent advances in copper sulfide nanoparticles for cancer diagnosis and therapy.

Mater Today Bio. 2025-8-13

[2]
Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities.

Front Mol Biosci. 2025-5-13

[3]
Current status and recent progress of nanomaterials in transcatheter arterial chemoembolization therapy for hepatocellular carcinoma.

World J Clin Oncol. 2025-4-24

[4]
Comparison of structural, optical, and thermal properties in MoS based nanocomposites into cancer therapy.

J Mater Sci Mater Med. 2025-4-25

[5]
Insights into the history and trends of nanotechnology for the treatment of hepatocellular carcinoma: a bibliometric-based visual analysis.

Discov Oncol. 2025-4-7

[6]
Targeted redox-responsive peptide for arterial chemoembolization therapy of orthotropic hepatocellular carcinoma.

Abdom Radiol (NY). 2024-11

[7]
Plasmonic and Photothermal Effects of CuS Nanoparticles Biosynthesized from Acid Mine Drainage with Potential Drug Delivery Applications.

Int J Mol Sci. 2023-11-18

[8]
Photothermal therapy of copper incorporated nanomaterials for biomedicine.

Biomater Res. 2023-11-24

[9]
Analysis of temperature behavior in biological tissue in photothermal therapy according to laser irradiation angle.

Bioengineered. 2023-12

[10]
Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing.

J Nanobiotechnology. 2023-8-10

本文引用的文献

[1]
Biocompatible tumor-targeting nanocomposites based on CuS for tumor imaging and photothermal therapy.

RSC Adv. 2018-2-6

[2]
Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy.

Cancer Nanotechnol. 2020

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Nanomicro Lett. 2020-7-5

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Massive Intracellular Remodeling of CuS Nanomaterials Produces Nontoxic Bioengineered Structures with Preserved Photothermal Potential.

ACS Nano. 2021-6-22

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Antifouling Dendrimer-Entrapped Copper Sulfide Nanoparticles Enable Photoacoustic Imaging-Guided Targeted Combination Therapy of Tumors and Tumor Metastasis.

ACS Appl Mater Interfaces. 2021-2-10

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Synergistic Photothermal and Photodynamic Therapy for Effective Implant-Related Bacterial Infection Elimination and Biofilm Disruption Using CuS Nanoparticles.

ACS Biomater Sci Eng. 2019-11-11

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Transcatheter arterial chemoembolization combined with simultaneous DynaCT-guided microwave ablation in the treatment of small hepatocellular carcinoma.

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Reversed Lipid-Based Nanoparticles Dispersed in Iodized Oil for Transarterial Chemoembolization.

ACS Appl Mater Interfaces. 2019-5-30

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