Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
Colloids Surf B Biointerfaces. 2022 Jan;209(Pt 1):112208. doi: 10.1016/j.colsurfb.2021.112208. Epub 2021 Nov 8.
Infection, oxidative stress, and inflammation are the major obstacles to cutaneous wound healing. Designing adhesive wound dressings with inherent antibacterial and antioxidant properties are highly desirable. Herein, a series of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-doped multifunctional hydrogels were facilely prepared by combining quaternized carboxymethyl chitosan (QCMCS) and oxidized hyaluronate (HA-CHO). Schiff base crosslinking between amino groups in QCMCS and aldehyde groups in HA-CHO not only constructed hydrogel networks but also endowed hydrogels with good self-healing property. The hydrogel exhibited adjustable tissue adhesiveness, degradability, and rheological properties by changing the content of TEMPO groups. Moreover, the hydrogels presented excellent inherent antibacterial and antioxidant properties, along with the porous structures, swelling ability, good cytocompatibility and low hemolysis ratio, which are beneficial to promoting wound healing process. Overall, the TEMPO hydrogel showed excellent therapeutic effect in mice skin defect model, giving the hydrogel with fitness as wound dressings for treating skin wounds.
感染、氧化应激和炎症是皮肤伤口愈合的主要障碍。设计具有固有抗菌和抗氧化性能的粘性伤口敷料是非常需要的。本文通过结合季铵化羧甲基壳聚糖（QCMCS）和氧化透明质酸（HA-CHO），简便地制备了一系列 2,2,6,6-四甲基哌啶-1-氧自由基（TEMPO）掺杂的多功能水凝胶。QCMCS 中的氨基与 HA-CHO 中的醛基之间的席夫碱交联不仅构建了水凝胶网络，而且赋予了水凝胶良好的自修复性能。通过改变 TEMPO 基团的含量，水凝胶表现出可调的组织粘附性、降解性和流变性能。此外，水凝胶具有优异的固有抗菌和抗氧化性能，以及多孔结构、高溶胀能力、良好的细胞相容性和低溶血率，这有利于促进伤口愈合过程。总的来说，TEMPO 水凝胶在小鼠皮肤缺损模型中表现出了优异的治疗效果，使水凝胶适合用作治疗皮肤伤口的伤口敷料。
