Coleman Tim, Clark Miranda, Welch Charlie, Whitemore Rachel, Leonardi-Bee Jo, Cooper Sue, Hewitt Catherine, Jones Matthew, Sutton Stephen, Watson Judith, Daykin Karen, Ussher Michael, Parrott Steve, Naughton Felix
Centre for Academic Primary Care, Medical School, University of Nottingham, Nottingham, Nottinghamshire, England.
York Trials Unit, University of York, York, Yorkshire, England.
Addiction. 2022 Apr;117(4):1079-1094. doi: 10.1111/add.15715. Epub 2021 Nov 5.
To test the efficacy of 'MiQuit', a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy.
Multicentre, open, two-arm, parallel-group, superiority randomised controlled trial (RCT) and a trial sequential analysis (TSA) meta-analysis combining trial findings with two previous ones.
Twenty-four English hospital antenatal clinics.
A total of 1002 pregnant women who were ≥16 years old, were ≤25 weeks gestation and smoked ≥1 daily cigarette and accepted information on cessation with no requirement to set quit dates.
UC or UC plus 'MiQuit': 12 weeks of tailored, smoking cessation text messages focussed on inducing and aiding cessation.
Primary outcome: biochemically validated cessation between 4 weeks after randomisation and late pregnancy.
shorter and non-validated abstinence periods, pregnancy outcomes and incremental cost-effectiveness ratios.
RCT: cessation was 5.19% (26/501) and 4.59% (23/501) in MiQuit and UC groups (adjusted odds ratio [adj OR] for quitting with MiQuit versus UC, 95% CI = 1.15 [0.65-2.04]); other abstinence findings were similar, with higher point estimates. Primary outcome ascertainment was 61.7% (309) and 67.3% (337) in MiQuit and UC groups with 71.1% (54/76) and 69.5% (41/59) abstinence validation rates, respectively. Pregnancy outcomes were similar and the incremental cost per quality-adjusted life year was -£1118 (95% CI = -£4806-£1911). More MiQuit group women reported making at least one quit attempt (adj OR [95% CI]) for making an attempt, 1.50 (1.07-2.09). TSA meta-analysis: this found no significant difference in prolonged abstinence between MiQuit and UC (pooled OR = 1.49, adjusted 95% CI = 0.62-3.60).
Irrespective of whether they want to try quitting, when offered a tailored, self-help, text message stop smoking programme for pregnancy (MiQuit) as an adjunct to usual care, pregnant women are not more likely to stop smoking until childbirth but they report more attempts at stopping smoking.
测试“MiQuit”（一种专门为孕期设计的、自助式的戒烟短信计划）作为孕期戒烟常规护理（UC）辅助手段的效果。
多中心、开放性、双臂、平行组、优效性随机对照试验（RCT）以及一项试验序贯分析（TSA）荟萃分析，将本试验结果与之前的两项试验结果相结合。
英国24家医院的产前诊所。
总共1002名年龄≥16岁、妊娠≤25周、每天至少吸1支烟且接受戒烟信息但不要求设定戒烟日期的孕妇。
常规护理或常规护理加“MiQuit”：为期12周的专门定制的戒烟短信，重点在于诱导和辅助戒烟。
主要结局：随机分组后4周直至妊娠晚期经生化验证的戒烟情况。
较短的且未经验证的戒烟期、妊娠结局以及增量成本效益比。
随机对照试验：MiQuit组和常规护理组的戒烟率分别为5.19%（26/501）和4.59%（23/501）（MiQuit组与常规护理组相比的调整优势比[adj OR]，95%置信区间=1.15[0.65 - 2.04]）；其他戒烟结果相似，但点估计值更高。MiQuit组和常规护理组的主要结局确定率分别为61.7%（309）和67.3%（337），戒烟验证率分别为71.1%（54/76）和69.5%（41/59）。妊娠结局相似，每质量调整生命年的增量成本为-1118英镑（95%置信区间=-4806英镑至1911英镑）。更多MiQuit组的女性报告至少尝试过一次戒烟（尝试戒烟的调整优势比[95%置信区间]，1.50[1.07 - 2.09]）。试验序贯分析荟萃分析：该分析发现MiQuit组和常规护理组在延长戒烟方面无显著差异（合并优势比=1.49，调整后的95%置信区间=0.62 - 3.60）。
无论孕妇是否想要尝试戒烟，当提供一种专门为孕期设计的、自助式的戒烟短信计划（“MiQuit”）作为常规护理的辅助手段时，孕妇在分娩前戒烟的可能性并不会增加，但她们报告尝试戒烟的次数更多。
