University of Wisconsin-Milwaukee, Milwaukee, USA.
Chembiochem. 2022 Feb 4;23(3):e202100366. doi: 10.1002/cbic.202100366. Epub 2021 Oct 25.
Hydrogen peroxide is the most stable reactive oxygen species generated endogenously, participating in numerous physiological processes and abnormal pathological conditions. Mounting evidence suggests that a higher level of H O exists in various disease conditions. Thus, H O functions as an ideal target for site-specific bioimaging and therapeutic targeting. The unique reactivity of organoborons with H O provides a method for developing chemoselective molecules for biological and biomedical applications. This review highlights the design and application of boron-derived molecules for H O detection, and the utility of boron moieties toward masking reactive compounds leading to the development of metal prochelators and prodrugs for selectively delivering an active species at the target sites with elevated H O levels. Additionally, the emergence of H O -responsive theranostic agents consisting of both therapeutic and diagnostic moieties in one integrated system are discussed. The purpose of this review is to provide a better understanding of the role of boron-derived molecules toward biological and pharmacological applications.
过氧化氢是内源性生成的最稳定的活性氧物种，参与众多生理过程和异常病理条件。越来越多的证据表明，在各种疾病状态下存在更高水平的 H O。因此，H O 可作为特定部位生物成像和治疗靶向的理想目标。有机硼与 H O 的独特反应性为开发用于生物和生物医学应用的化学选择性分子提供了一种方法。本综述重点介绍了硼衍生分子用于 H O 检测的设计和应用，以及硼部分用于掩蔽反应性化合物的用途，从而开发出金属前螯合剂和前药，用于在 H O 水平升高的靶部位选择性递送至活性物质。此外，还讨论了由治疗和诊断部分组成的在一个集成系统中的 H O 响应治疗诊断剂的出现。本综述的目的是更好地了解硼衍生分子在生物学和药理学应用中的作用。
