评估 COVID-19 患者的瞳孔参数。
Evaluation of Pupillometric Parameters in Patients with COVID-19.
机构信息
Haydarpaşa Numune Training and Research Hospital, Department of Ophthalmology, University of Health Sciences, Istanbul, Turkey.
出版信息
Ocul Immunol Inflamm. 2023 Jan;31(1):39-43. doi: 10.1080/09273948.2021.1980811. Epub 2021 Oct 12.
PURPOSE
To investigate the pupillary diameter and pupillary light response in patients who have recovered from the COVID-19.
METHODS
Thirty two eyes of 32 patients with a history of COVID-19 in the last two months and 32 eyes of 32 age and sex-matched healthy controls were included in this prospective study. All patients had neurological symptoms. Dynamic and static pupillometry measurements were performed with the Sirius (CSO, Italy) corneal topography device.
RESULTS
Patients with COVID-19 had higher mean scotopic, mesopic, and photopic pupil diameters compared to the controls ( = .01, = .04, = .02, respectively). In dynamic pupillometry analysis, 0, 2, 8 and 16 second pupil diameter measurements were higher in COVID-19 patients ( = .02, = .04, = .04, = .04, respectively). There were no differences in the average speed of pupillary dilatation ( > .05).
CONCLUSION
Our findings suggest that the pupillary response, an indicator of autonomic nervous system activity, may be affected in COVID-19 patients with neurological symptoms.
目的
研究从 COVID-19 中康复的患者的瞳孔直径和瞳孔光反应。
方法
本前瞻性研究纳入了近两个月内有 COVID-19 病史的 32 名患者（32 只眼）和 32 名年龄和性别匹配的健康对照者（32 只眼）。所有患者均有神经系统症状。使用 Sirius（CSO，意大利）角膜地形图仪进行动态和静态瞳孔测量。
结果
与对照组相比，COVID-19 患者的暗适应、中间适应和明适应瞳孔直径平均值更高（= 0.01，= 0.04，= 0.02，分别）。在动态瞳孔测量分析中，COVID-19 患者的 0、2、8 和 16 秒瞳孔直径测量值更高（= 0.02，= 0.04，= 0.04，= 0.04，分别）。瞳孔扩张的平均速度没有差异（> 0.05）。
结论
我们的研究结果表明，瞳孔反应（自主神经系统活动的一个指标）可能会受到 COVID-19 伴有神经系统症状患者的影响。
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