Tirgar Mahtab, Hosseini Hadi, Jafari Milad, Shojaei Shahrokh, Abdollahi Amir, Jafari Aliakbar, Uzun Lokman, Goodarzi Vahabodin, Su Chia-Hung
Department of Biomedical Engineering, Islamic Azad University, Central Tehran Branch, Tehran, Iran.
Faculty of Engineering & Technology, University of Mazandaran, Babolsar, Iran.
J Biomater Sci Polym Ed. 2022 Mar;33(4):443-464. doi: 10.1080/09205063.2021.1992588. Epub 2021 Oct 22.
In this study, a novel biopolymer based on poly(glycerol sebacic)-urethane (PGS-U) and its nanocomposites containing Cloisite@30B were synthesized by facile approach in which the crosslinking was created by aliphatic hexamethylene diisocyanate (HDI) at room temperature and 80 °C. Moreover, metronidazole and tetracycline drugs were selected as target drugs and loaded into PGSU based nanocomposites. A uniform and continuous microstructure with smooth surface is observed in the case of pristine PGS-U sample. The continuity of microstructure is observed in the case of all bionanocomposites. XRD result confirmed an intercalated morphology for PGSU containing 5 wt% of clay nanoparticles with a d-spacing 3.4 nm. The increment of nanoclay content up to 5%, the ultimate tensile stress and elastic modulus were obtained nearly 0.32 and 0.83 MPa, which the latter was more than eight-fold than that of pristine PGS-U. A sustained release for both dugs was observed by 200 h. The slowest and controlled drug release rate was determined in the case of PGSU containing 5 wt% clay and cured at 80 °C. A non-Fickian diffusion can be concluded in the case of tetracycline release PGS-U/nanoclay bionanocomposites, while a Fickian process was detected in the case of metronidazole release by PGS-U/nanoclay bionanocomposites. As a result, the designed scaffold showed high flexibility, which makes it an appropriate option for utilization in the treatment of periodontal disease.
在本研究中，通过简便方法合成了一种基于聚（癸二酸甘油酯）-聚氨酯（PGS-U）的新型生物聚合物及其含有Cloisite@30B的纳米复合材料，其中在室温及80°C下通过脂肪族六亚甲基二异氰酸酯（HDI）进行交联。此外，选择甲硝唑和四环素药物作为目标药物并负载到基于PGSU的纳米复合材料中。在原始PGS-U样品中观察到具有光滑表面的均匀连续微观结构。在所有生物纳米复合材料中均观察到微观结构的连续性。X射线衍射结果证实了含有5 wt%粘土纳米颗粒且d间距为3.4 nm的PGSU具有插层形态。纳米粘土含量增加至5%时，获得的极限拉伸应力和弹性模量分别约为0.32和0.83 MPa，后者比原始PGS-U高出八倍多。两种药物均观察到持续200小时的释放。在含有5 wt%粘土并在80°C下固化的PGSU情况下，确定了最慢且可控的药物释放速率。对于四环素从PGS-U/纳米粘土生物纳米复合材料中的释放情况，可以得出非菲克扩散，而对于甲硝唑从PGS-U/纳米粘土生物纳米复合材料中的释放情况，检测到菲克过程。结果，所设计的支架显示出高柔韧性，这使其成为用于治疗牙周疾病的合适选择。
