State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Discovery Project Unit, HitGen Inc. Tianfu International Bio-Town, Chengdu, China.
Front Immunol. 2021 Sep 27;12:756920. doi: 10.3389/fimmu.2021.756920. eCollection 2021.
High glucose and fructose intake have been proven to display pro-inflammatory roles during the progression of inflammatory diseases. However, mannose has been shown to be a special type of hexose that has immune regulatory functions. In this review, we trace the discovery process of the regulatory functions of mannose and summarize some past and recent studies showing the therapeutic functions of mannose in inflammatory diseases. We conclude that treatment with mannose can suppress inflammation by inducing regulatory T cells, suppressing effector T cells and inflammatory macrophages, and increasing anti-inflammatory gut microbiome. By summarizing all the important findings, we highlight that mannose treatment is a safe and promising novel strategy to suppress inflammatory diseases, including autoimmune disease and allergic disease.
高糖和果糖的摄入已被证明在炎症性疾病的进展过程中具有促炎作用。然而，甘露糖已被证明是一种具有免疫调节功能的特殊己糖。在这篇综述中，我们追溯了甘露糖免疫调节功能的发现过程，并总结了一些过去和最近的研究表明甘露糖在炎症性疾病中的治疗作用。我们得出结论，甘露糖治疗可以通过诱导调节性 T 细胞、抑制效应 T 细胞和炎性巨噬细胞以及增加抗炎肠道微生物群来抑制炎症。通过总结所有重要的发现，我们强调甘露糖治疗是一种安全且有前途的抑制炎症性疾病的新策略，包括自身免疫性疾病和过敏性疾病。
