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Estimating cell type-specific differential expression using deconvolution.

作者信息

Jaakkola Maria K, Elo Laura L

机构信息

Department of Mathematics and Statistics, University of Turku, Yliopistonmäki, 20014, Turku, Finland.

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Tykistökatu 6, FI-20520, Turku, Finland.

出版信息

Brief Bioinform. 2022 Jan 17;23(1). doi: 10.1093/bib/bbab433.

Abstract
摘要

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Cell type-aware analysis of RNA-seq data.
Nat Comput Sci. 2021 Apr;1(4):253-261. doi: 10.1038/s43588-021-00055-6. Epub 2021 Apr 15.
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Computational deconvolution to estimate cell type-specific gene expression from bulk data.
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Benchmarking of cell type deconvolution pipelines for transcriptomics data.
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Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.
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Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes.
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Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology.
Bioinformatics. 2019 Jul 15;35(14):i436-i445. doi: 10.1093/bioinformatics/btz363.
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Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology.
Nat Commun. 2019 Jul 31;10(1):3417. doi: 10.1038/s41467-019-11052-9.
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