Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Plaza de Ramón y Cajal s/n, Madrid 28040, Spain..
Acta Biomater. 2022 Jan 1;137:44-52. doi: 10.1016/j.actbio.2021.10.011. Epub 2021 Oct 12.
Our contributions to mesoporous silica materials in the field of biomedicine are reported in this article. This perspective article represents our work in the basics of the material, preparing different ranges of mesoporous silica nanoparticles with different diameters and with varied pore sizes. We demonstrated the high loading capacity of these materials. Additionally, the possibility of functionalizing both internal and external surface with different organic or inorganic moieties allowed the development of stimuli-responsive features which allowed a proper control on the administered dose. In addition, we have demonstrated that these carriers are not toxic, and we have also ensured that the load reaches its destination without affecting healthy tissues. STATEMENT OF SIGNIFICANCE: This paper presents my personal opinion and background on a hot topic as mesoporous silica nanoparticles for drug delivery. To this aim it provides a comprehensive and historical overview on the innovative contributions of my research group to this rapidly expanding field of research.
本文报道了我们在介孔硅材料领域在生物医药方面的贡献。这篇观点文章代表了我们在材料基础、制备不同直径和不同孔径的介孔硅纳米粒子方面的工作。我们展示了这些材料的高负载能力。此外，通过内部和外部表面的不同有机或无机基团进行功能化的可能性，使发展具有刺激响应特性成为可能，从而可以对给药剂量进行适当的控制。此外，我们已经证明这些载体没有毒性，并且我们还确保负载物到达目的地而不会影响健康组织。意义声明：本文介绍了我个人对介孔硅纳米粒子作为药物传递载体这一热门话题的观点和背景。为此，它提供了对我研究小组在这一快速发展的研究领域的创新贡献的全面和历史概述。
