墨西哥学龄儿童过敏性鼻炎的患病率及相关危险因素:全球哮喘网络第一阶段研究
Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I.
作者信息
García-Almaraz Roberto, Reyes-Noriega Nayely, Del-Río-Navarro Blanca Estela, Berber Arturo, Navarrete-Rodríguez Elsy Maureen, Ellwood Philippa, García Marcos Álvarez Luis
机构信息
Hospital Infantil de Tamaulipas, Ciudad Victoria, Tamaulipas, Mexico.
Servicio de Alergia e Inmunología, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
出版信息
World Allergy Organ J. 2020 Dec 5;14(1):100492. doi: 10.1016/j.waojou.2020.100492. eCollection 2021 Jan.
BACKGROUND
The International Study of Asthma and Allergies in Childhood (ISAAC) showed a wide variability in prevalence and severity of allergic rhinitis (AR) and rhinoconjunctivitis (ARC), in addition to other atopic diseases (Asher et al, 2006). The Global Asthma Network (GAN) has continued to study these conditions.
OBJECTIVE
To estimate the prevalence of AR and ARC in children and adolescents in Mexico and to assess their association with different risk factors.
METHODS
GAN Phase I is a cross-sectional, multicentre survey carried out in 15 centres corresponding to 14 Mexican cities throughout 2016-2019 using the validated Spanish language version of the GAN Phase I questionnaires. The questionnaires were completed by 35 780 parents of 6-7 year old primary school pupils (children) and by 41 399 adolescents, 13-14 years old.
RESULTS
The current and cumulative prevalence of AR was higher in the adolescents (26.2-37.5%, respectively) in comparison to the children (17.9-24.9%, respectively), especially in female participants. This tendency was also observed in the current prevalence of ARC, where 15.1% of female adolescents reported nasal symptoms accompanied with itchy-watery eyes in the past year. The most important risk factors for AR and ARC were the presence of wheezing in the past 12 months, wheezing in the first year of life, the previous diagnosis of asthma and eczema symptoms. Furthermore, allergic symptoms had a negative tendency concerning altitude.
CONCLUSION
This is the largest AR epidemiological study ever conducted in Mexico. It shows an increase in AR prevalence, as well as significant associations with modifiable risk factors, which could help to establish recommendations to reduce the burden of this condition.
背景
儿童哮喘和过敏国际研究(ISAAC)表明,除其他特应性疾病外,过敏性鼻炎(AR)和鼻结膜炎(ARC)的患病率和严重程度存在很大差异(阿舍等人,2006年)。全球哮喘网络(GAN)一直在研究这些疾病。
目的
估计墨西哥儿童和青少年中AR和ARC的患病率,并评估它们与不同风险因素的关联。
方法
GAN第一阶段是一项横断面多中心调查,于2016 - 2019年在墨西哥14个城市的15个中心进行,使用经过验证的西班牙语版GAN第一阶段问卷。问卷由35780名6 - 7岁小学生(儿童)的家长和41399名13 - 14岁青少年填写。
结果
与儿童(分别为17.9% - 24.9%)相比,青少年中AR的当前患病率和累积患病率更高(分别为26.2% - 37.5%),尤其是女性参与者。在ARC的当前患病率中也观察到这种趋势,过去一年中有15.1%的女性青少年报告有鼻部症状并伴有眼睛瘙痒流泪。AR和ARC最重要的风险因素是过去12个月内出现喘息、出生后第一年喘息、先前诊断为哮喘和湿疹症状。此外,过敏症状与海拔高度呈负相关趋势。
结论
这是墨西哥有史以来规模最大的AR流行病学研究。它显示了AR患病率的增加,以及与可改变风险因素的显著关联,这有助于制定减轻这种疾病负担的建议。