Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
BMC Complement Med Ther. 2021 Oct 20;21(1):265. doi: 10.1186/s12906-021-03434-8.
Oils in traditional medicine are important products and used routinely for therapeutic purposes. Rose oil (Rosa damascene Mill), a product of Persian medicine, is advised for the treatment of Infectious diseases related to the female genitourinary tract. In the present study, R. damascena petal oil, aqueous, and hydroalcoholic extracts were evaluated for their in vitro antibacterial and anti-Trichomonas vaginalis effects.
Anti-trichomonas activity evaluation of extracts and oil were assayed by the Homocytometery method. Their antibacterial effects against Escherichia coli, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and clinically isolated Group B Streptococcus were assayed by broth microdilution in 96-well plates.
The MIC of hydroalcoholic and aqueous extracts ranged from 25-50 and 25-100 mg/ml, respectively. Rose oil at all administered doses failed to show any antibacterial activity.
All extracts and oil concentrations showed some degree of growth inhibition activity on T. vaginalis; however, hydroalcoholic extract was more efficient.
传统医学中的油类是重要的产品，常用于治疗目的。玫瑰油（Rosa damascene Mill）是波斯医学的产物，被建议用于治疗与女性泌尿生殖道相关的传染病。在本研究中，评估了大马士革玫瑰花瓣油、水提物和水醇提物的体外抗菌和抗阴道毛滴虫活性。
采用细胞计数法评估提取物和油的抗滴虫活性。采用 96 孔板微量肉汤稀释法测定其对大肠杆菌、耐甲氧西林金黄色葡萄球菌、铜绿假单胞菌和临床分离的 B 组链球菌的抗菌作用。
水醇提物和水提物的 MIC 范围分别为 25-50 和 25-100mg/ml。玫瑰油在所有给药剂量下均未显示出任何抗菌活性。
所有提取物和油浓度对阴道毛滴虫均显示出一定程度的生长抑制活性；然而，水醇提物更为有效。
