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ALDH2 促进子宫内膜癌增殖并构建临床生存预后模型。

ALDH2 promotes uterine corpus endometrial carcinoma proliferation and construction of clinical survival prognostic model.

机构信息

School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, Shandong, PR China.

Department of Medical Laboratory, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei, PR China.

出版信息

Aging (Albany NY). 2021 Oct 20;13(20):23588-23602. doi: 10.18632/aging.203605.

DOI:10.18632/aging.203605
PMID:34670872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8580334/
Abstract

UCEC is one of the three common malignant tumors of the female reproductive tract. According to reports, the cure rate of early UCEC can reach 95%. Therefore, the development of prognostic markers will help UCEC patients to find the disease earlier and develop treatment earlier. The ALDH family was first discovered to be the essential gene of the ethanol metabolism pathway in the body. Recent studies have shown that ALDH can participate in the regulation of cancer. In our research, we explored the expression of the ALDH family in 33 cancers. It was found that ALDH2 was abnormally expressed in UCEC. Besides, and experiments were conducted to explore the effect of ALDH2 expression on the proliferation of UCEC cell lines. Meanwhile, the change of its expression is not due to gene mutations, but is regulated by miR-135-3p. At the same time, the impact of ALDH2 changes on the survival of UCEC patients is deeply discussed. Finally, a nomogram for predicting survival was constructed, with a C-index of 0.798 and AUC of 0.764. This study suggests that ALDH2 may play a crucial role in UCEC progression and has the potential as a prognostic biomarker of UCEC.

摘要

UCEC 是女性生殖道三大常见恶性肿瘤之一。据报道，早期 UCEC 的治愈率可达 95%。因此，预后标志物的发展将有助于 UCEC 患者更早地发现疾病并进行治疗。ALDH 家族最初被发现是体内乙醇代谢途径的必需基因。最近的研究表明，ALDH 可以参与癌症的调控。在我们的研究中，我们探讨了 ALDH 家族在 33 种癌症中的表达情况。结果发现，ALDH2 在 UCEC 中异常表达。此外，进行了 和 实验，以探讨 ALDH2 表达对 UCEC 细胞系增殖的影响。同时，其表达的变化不是由于基因突变，而是受 miR-135-3p 调控。同时，还深入探讨了 ALDH2 变化对 UCEC 患者生存的影响。最后，构建了一个用于预测生存的列线图，其 C 指数为 0.798，AUC 为 0.764。本研究表明，ALDH2 可能在 UCEC 的进展中发挥关键作用，有望成为 UCEC 的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/61dd105b79b1/aging-13-203605-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/baf7641b8709/aging-13-203605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/b76591d69d3b/aging-13-203605-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/0e52ffce1833/aging-13-203605-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/5c5b24182ee0/aging-13-203605-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/1ce14dd46f12/aging-13-203605-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/80e8632f6389/aging-13-203605-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/61dd105b79b1/aging-13-203605-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/baf7641b8709/aging-13-203605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/b76591d69d3b/aging-13-203605-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/0e52ffce1833/aging-13-203605-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/5c5b24182ee0/aging-13-203605-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/1ce14dd46f12/aging-13-203605-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/80e8632f6389/aging-13-203605-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/8580334/61dd105b79b1/aging-13-203605-g007.jpg

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