SOX-10、HMB-45和Melan-A在良性黑素细胞性病变中的比较
Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions.
作者信息
Dass Sabrina E, Huizenga Taryn, Farshchian Mehdi, Mehregan Darius R
机构信息
Wayne State University School of Medicine, Detroit, MI, USA.
Department of Dermatology, Wayne State University, Detroit, MI, USA.
出版信息
Clin Cosmet Investig Dermatol. 2021 Oct 5;14:1419-1425. doi: 10.2147/CCID.S333376. eCollection 2021.
PURPOSE
Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.
METHODS
SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.
RESULTS
Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).
CONCLUSION
SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.
目的
在皮肤病理学中使用不同的免疫组织化学染色来对黑素细胞进行染色，并诊断良性和恶性黑素细胞病变。
方法
使用SOX-10、HMB-45和Melan-A免疫组织化学染色来评估32例经组织学诊断为雀斑样痣的活检标本。对每种免疫组织化学染色所染黑素细胞的总数进行计数，并从两次读数中获得平均计数。
结果
数据分析显示这三种免疫染色在黑素细胞染色方面存在显著差异（p = 0.0010，方差分析）。SOX-10所染黑素细胞比HMB-45多0.195个（p = 0.0026）。同样，Melan-A所染黑素细胞比HMB-45多0.195个（p = 0.0011）。然而，SOX-10和Melan-A之间的差异无统计学意义（p = 0.9810）。
结论
SOX-10和Melan-A免疫染色所染黑素细胞比HMB-45多。Melan-A和SOX-10之间未观察到显著差异。
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