• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SOX-10、HMB-45和Melan-A在良性黑素细胞性病变中的比较

Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions.

作者信息

Dass Sabrina E, Huizenga Taryn, Farshchian Mehdi, Mehregan Darius R

机构信息

Wayne State University School of Medicine, Detroit, MI, USA.

Department of Dermatology, Wayne State University, Detroit, MI, USA.

出版信息

Clin Cosmet Investig Dermatol. 2021 Oct 5;14:1419-1425. doi: 10.2147/CCID.S333376. eCollection 2021.

DOI:10.2147/CCID.S333376
PMID:34675577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8502009/
Abstract

PURPOSE

Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.

METHODS

SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.

RESULTS

Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).

CONCLUSION

SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.

摘要

目的

在皮肤病理学中使用不同的免疫组织化学染色来对黑素细胞进行染色，并诊断良性和恶性黑素细胞病变。

方法

使用SOX-10、HMB-45和Melan-A免疫组织化学染色来评估32例经组织学诊断为雀斑样痣的活检标本。对每种免疫组织化学染色所染黑素细胞的总数进行计数，并从两次读数中获得平均计数。

结果

数据分析显示这三种免疫染色在黑素细胞染色方面存在显著差异（p = 0.0010，方差分析）。SOX-10所染黑素细胞比HMB-45多0.195个（p = 0.0026）。同样，Melan-A所染黑素细胞比HMB-45多0.195个（p = 0.0011）。然而，SOX-10和Melan-A之间的差异无统计学意义（p = 0.9810）。

结论

SOX-10和Melan-A免疫染色所染黑素细胞比HMB-45多。Melan-A和SOX-10之间未观察到显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/a6df64186f60/CCID-14-1419-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/2c2595b9d477/CCID-14-1419-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/96b657bb743c/CCID-14-1419-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/a6df64186f60/CCID-14-1419-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/2c2595b9d477/CCID-14-1419-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/96b657bb743c/CCID-14-1419-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c4/8502009/a6df64186f60/CCID-14-1419-g0003.jpg

相似文献

1
Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions.SOX-10、HMB-45和Melan-A在良性黑素细胞性病变中的比较
Clin Cosmet Investig Dermatol. 2021 Oct 5;14:1419-1425. doi: 10.2147/CCID.S333376. eCollection 2021.
2
Melanocytic marker Melan-A detects molluscum contagiosum bodies.黑素细胞标志物Melan-A可检测传染性软疣小体。
J Histotechnol. 2022 Mar;45(1):36-38. doi: 10.1080/01478885.2021.1964872. Epub 2021 Aug 19.
3
Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ.日光性雀斑样痣和原位黑素瘤中MiTF、Melan-A、HMB-45和Mel-5的定量比较。
J Cutan Pathol. 2011 Oct;38(10):775-9. doi: 10.1111/j.1600-0560.2011.01763.x. Epub 2011 Jul 29.
4
Melan-A/Mart-1 expression in various melanocytic lesions and in non-melanocytic soft tissue tumours.Melan-A/Mart-1在各种黑素细胞性病变及非黑素细胞性软组织肿瘤中的表达。
Histopathology. 1999 Jun;34(6):517-25. doi: 10.1111/j.1365-2559.1999.00679.x.
5
Melan-A positive dermal cells in malignant melanoma in situ.原位恶性黑色素瘤中的Melan-A阳性真皮细胞。
J Cutan Pathol. 2015 Jun;42(6):388-93. doi: 10.1111/cup.12473. Epub 2015 Apr 14.
6
Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis.黑素A：在区分日光损伤皮肤原位黑色素瘤和色素性光化性角化病方面并非有用的标志物。
Am J Dermatopathol. 2004 Oct;26(5):364-6. doi: 10.1097/00000372-200410000-00003.
7
HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas.对于原发性口腔和鼻腔黏膜黑色素瘤的免疫组织化学诊断，HMB-45可能是比S-100或Melan-A更敏感的标志物。
J Oral Pathol Med. 2005 Oct;34(9):540-5. doi: 10.1111/j.1600-0714.2005.00340.x.
8
Melanocytes in nonlesional sun-exposed skin: a multicenter comparative study.非皮损性日光暴露皮肤中的黑素细胞：一项多中心对比研究。
J Am Acad Dermatol. 2011 Dec;65(6):1186-93. doi: 10.1016/j.jaad.2010.10.039. Epub 2011 Jun 17.
9
Immunohistochemical diagnosis of malignant melanoma of the conjunctiva and uvea: comparison of the novel antibody against melan-A with S100 protein and HMB-45.结膜和葡萄膜恶性黑色素瘤的免疫组织化学诊断：新型抗黑素A抗体与S100蛋白及HMB-45的比较
Melanoma Res. 2000 Aug;10(4):350-4. doi: 10.1097/00008390-200008000-00006.
10
Comparison of immunohistochemical staining of the novel antibody melan-A with S100 protein and HMB-45 in malignant melanoma and melanoma variants.新型抗体黑素-A与S100蛋白及HMB-45在恶性黑色素瘤及黑色素瘤变异型中的免疫组化染色比较
Histopathology. 1998 Feb;32(2):139-46. doi: 10.1046/j.1365-2559.1998.00312.x.

引用本文的文献

1
Primary adrenal melanoma with extensive metastasis: a case report and literature review.原发性肾上腺黑色素瘤伴广泛转移：一例报告及文献复习
Front Oncol. 2025 Aug 14;15:1654218. doi: 10.3389/fonc.2025.1654218. eCollection 2025.
2
Comparative study of different treatment modalities for melasma: introducing a novel nanotechnology-based tranexamic acid microemulsion.黄褐斑不同治疗方式的比较研究：引入一种新型基于纳米技术的氨甲环酸微乳剂
Arch Dermatol Res. 2025 Jun 2;317(1):792. doi: 10.1007/s00403-025-04294-9.
3
Cryoblebbing with 5-fluorouracil versus cryoblebbing with melanocyte keratinocyte transplant procedure or cryoblebbing alone in treatment of stable vitiligo.

本文引用的文献

1
Immunohistochemical Expression of p16 in Melanocytic Lesions: An Updated Review and Meta-analysis.p16 在黑素细胞病变中的免疫组化表达：更新综述和荟萃分析。
Arch Pathol Lab Med. 2018 Jul;142(7):815-828. doi: 10.5858/arpa.2017-0435-RA.
2
A quantitative comparison between SOX10 and MART-1 immunostaining to detect melanocytic hyperplasia in chronically sun-damaged skin.在慢性日光损伤皮肤中，比较SOX10和MART-1免疫染色检测黑素细胞增生的定量分析。
J Cutan Pathol. 2018 Apr;45(4):263-268. doi: 10.1111/cup.13115. Epub 2018 Feb 15.
3
Unstable solar lentigo: A defined separate entity.
5-氟尿嘧啶冷冻水疱疗法与黑素细胞角质形成细胞移植联合冷冻水疱疗法或单纯冷冻水疱疗法治疗稳定期白癜风的比较
Arch Dermatol Res. 2025 Jan 18;317(1):290. doi: 10.1007/s00403-024-03735-1.
4
The Role of Artificial Intelligence in Early Diagnosis and Molecular Classification of Head and Neck Skin Cancers: A Multidisciplinary Approach.人工智能在头颈部皮肤癌早期诊断和分子分类中的作用：一种多学科方法。
Diagnostics (Basel). 2024 Jul 10;14(14):1477. doi: 10.3390/diagnostics14141477.
5
Dendritic Melanocytic Hyperplasia in Pterygia: A Potential Source of Diagnostic Confusion with Primary Acquired Melanosis.翼状胬肉中的树突状黑素细胞增生：与原发性后天性黑素沉着症诊断混淆的潜在来源。
Ocul Oncol Pathol. 2023 Aug;9(1-2):48-55. doi: 10.1159/000530514. Epub 2023 Apr 7.
6
Cutaneous Melanoma: A Review of Multifactorial Pathogenesis, Immunohistochemistry, and Emerging Biomarkers for Early Detection and Management.皮肤黑色素瘤：多因素发病机制、免疫组织化学及早期检测和管理新兴生物标志物的综述。
Int J Mol Sci. 2023 Nov 1;24(21):15881. doi: 10.3390/ijms242115881.
7
Standardized Computer-Assisted Analysis of 5-hmC Immunoreactivity in Dysplastic Nevi and Superficial Spreading Melanomas.发育异常痣和浅表扩散性黑色素瘤中5-羟甲基胞嘧啶免疫反应性的标准化计算机辅助分析
Int J Mol Sci. 2023 Sep 28;24(19):14711. doi: 10.3390/ijms241914711.
8
A Disguising Fast-Growing Metachronous Melanoma and COVID-19.一例隐匿性快速生长的异时性黑色素瘤与新冠肺炎
Cureus. 2023 Mar 13;15(3):e36108. doi: 10.7759/cureus.36108. eCollection 2023 Mar.
9
Standardized Computer-Assisted Analysis of PRAME Immunoreactivity in Dysplastic Nevi and Superficial Spreading Melanomas.标准计算机辅助分析在发育不良性痣和浅表扩散性黑素瘤中 PRAME 的免疫反应性。
Int J Mol Sci. 2023 Mar 28;24(7):6388. doi: 10.3390/ijms24076388.
10
The Importance of Immunohistochemistry in the Evaluation of Tumor Depth of Primary Cutaneous Melanoma.免疫组织化学在原发性皮肤黑色素瘤肿瘤深度评估中的重要性。
Diagnostics (Basel). 2023 Mar 7;13(6):1020. doi: 10.3390/diagnostics13061020.
不稳定型日光性雀斑样痣：一种明确的独立实体。
Australas J Dermatol. 2016 Aug;57(3):229-34. doi: 10.1111/ajd.12447. Epub 2016 Feb 2.
4
Diagnosis and management of lentigo maligna: a review.恶性雀斑样痣的诊断与管理：综述
Drugs Context. 2015 May 29;4:212281. doi: 10.7573/dic.212281. eCollection 2015.
5
SOX10: a useful marker for identifying metastatic melanoma in sentinel lymph nodes.SOX10：一种用于识别前哨淋巴结中转移性黑色素瘤的有用标志物。
Appl Immunohistochem Mol Morphol. 2015 Feb;23(2):109-12. doi: 10.1097/PAI.0000000000000097.
6
Differences in tumor thickness between hematoxylin and eosin and Melan-A immunohistochemically stained primary cutaneous melanomas.苏木精和伊红染色与Melan-A免疫组化染色的原发性皮肤黑色素瘤之间肿瘤厚度的差异。
Am J Dermatopathol. 2013 Feb;35(1):56-63. doi: 10.1097/DAD.0b013e31825ba933.
7
Immunohistochemistry of melanocytic proliferations.黑素细胞增生的免疫组织化学染色。
Arch Pathol Lab Med. 2011 Jul;135(7):853-9. doi: 10.5858/2009-0717-RAR.1.
8
Distinction of melanoma in situ from solar lentigo on sun-damaged skin using morphometrics and MITF immunohistochemistry.利用形态计量学和MITF免疫组织化学区分日光损伤皮肤上的原位黑素瘤与日光性雀斑样痣。
Am J Dermatopathol. 2011 Aug;33(6):573-8. doi: 10.1097/DAD.0b013e3182093b13.
9
Melan-a-positive "pseudomelanocytic nests": a pitfall in the histopathologic and immunohistochemical diagnosis of pigmented lesions on sun-damaged skin.黑素-a阳性“假黑素细胞巢”：日光损伤皮肤色素沉着性病变组织病理学和免疫组化诊断中的一个陷阱
Am J Dermatopathol. 2009 May;31(3):305-8. doi: 10.1097/DAD.0b013e31819d3769.
10
Immunohistochemical characteristics of melanoma.黑色素瘤的免疫组织化学特征
J Cutan Pathol. 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x.