Araújo Ana Margarida, Carvalho Félix, Guedes de Pinho Paula, Carvalho Márcia
Associate Laboratory i4HB, Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
UCIBIO-Applied Molecular Biosciences Unit, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira nº228, 4050-313 Porto, Portugal.
Metabolites. 2021 Oct 9;11(10):692. doi: 10.3390/metabo11100692.
Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metabolic responses and altered biological pathways that various stressful stimuli cause in many organisms. The present review focuses on the analytical platforms and the typical workflow employed in toxicometabolomic studies, and gives an overview of recent exploratory research that applied metabolomics in various areas of toxicology.
鉴于传统和新出现的有毒物质具有很高的生物学影响，迫切需要对这些物质对生物体的危害和风险进行敏感而全面的评估。从这个意义上说，毒理代谢组学作为生命科学中一个新兴且不断发展的领域应运而生，它利用代谢组学来提供新的易感性、暴露和/或效应生物标志物集；并详细表征各种应激刺激在许多生物体中引起的代谢反应和改变的生物途径。本综述重点关注毒理代谢组学研究中使用的分析平台和典型工作流程，并概述了最近在毒理学各个领域应用代谢组学的探索性研究。
