Precision Health, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Japan.
School of Health Innovation, Kanagawa University of Human Services Graduate School, Kawasaki, Japan.
J Occup Health. 2021 Jan;63(1):e12275. doi: 10.1002/1348-9585.12275.
The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of Japanese office workers.
The present study is a secondary analysis of a subset of participants from a randomized controlled trial. Participants were 179 employees from 5 companies in Tokyo who participated as the intervention group in a 3-month lifestyle intervention study among office workers with metabolic syndrome or at risk of metabolic syndrome. All intervention-group participants used a mobile app and a wearable device. The final population for analysis in the present study were 173 participants. Cholesterol measures were derived from participants' annual health check-up data in the fiscal year preceding their inclusion in the study. Multiple linear regression models were used to determine the association between exposures and outcome.
Overall, stress levels were significantly and inversely associated with LDL-C (-7.12 mg/dl; 95% CI: -11.78, -2.45) and LDL-C/HDL-C ratio (-0.16 mg/dl; 95% CI: -0.27, -0.04) per standard deviation increase. Compared to average TST 5.9-7.2 hours, average TST of 4.0-5.3 hours (-4.82 mg/dl; 95% CI: -9.22, -0.43) was inversely associated with HDL-C.
Incremental increases of stress were significantly and inversely associated with LDL-C and LDL-C/HDL-C ratio. The shortest average TST was inversely associated with HDL-C. The results should be interpreted with care given certain methodological limitations.
本研究旨在探讨基于简明工作压力问卷（BJSQ）的总睡眠时间（TST）和职业压力与日本上班族胆固醇水平的关系。
本研究是一项随机对照试验的亚组分析。参与者是来自东京 5 家公司的 179 名员工，他们作为代谢综合征或代谢综合征高危人群的上班族 3 个月生活方式干预研究的干预组参加了该研究。所有干预组参与者均使用移动应用程序和可穿戴设备。本研究的最终分析人群为 173 名参与者。胆固醇测量值来自参与者在纳入研究前一年的年度健康检查数据。使用多元线性回归模型确定暴露与结局之间的关联。
总体而言，压力水平与 LDL-C（-7.12mg/dl；95%CI：-11.78，-2.45）和 LDL-C/HDL-C 比值（-0.16mg/dl；95%CI：-0.27，-0.04）呈显著负相关，每标准差增加。与平均 TST 5.9-7.2 小时相比，平均 TST 为 4.0-5.3 小时（-4.82mg/dl；95%CI：-9.22，-0.43）与 HDL-C 呈负相关。
压力的递增与 LDL-C 和 LDL-C/HDL-C 比值呈显著负相关。最短的平均 TST 与 HDL-C 呈负相关。鉴于某些方法学限制，结果应谨慎解释。
