Lim Jong-Woo, Ahn Yu-Rim, Park Geunseon, Kim Hyun-Ouk, Haam Seungjoo
Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seoul 03722, Korea.
Division of Chemical Engineering and Bioengineering, College of Art, Culture and Engineering, Kangwon National University, Chuncheon-si 24341, Gangwon-do, Korea.
Pharmaceutics. 2021 Sep 27;13(10):1570. doi: 10.3390/pharmaceutics13101570.
The coronavirus disease (COVID-19) pandemic poses serious global health concerns with the continued emergence of new variants. The periodic outbreak of novel emerging and re-emerging infectious pathogens has elevated concerns and challenges for the future. To develop mitigation strategies against infectious diseases, nano-based approaches are being increasingly applied in diagnostic systems, prophylactic vaccines, and therapeutics. This review presents the properties of various nanoplatforms and discusses their role in the development of sensors, vectors, delivery agents, intrinsic immunostimulants, and viral inhibitors. Advanced nanomedical applications for infectious diseases have been highlighted. Moreover, physicochemical properties that confer physiological advantages and contribute to the control and inhibition of infectious diseases have been discussed. Safety concerns limit the commercial production and clinical use of these technologies in humans; however, overcoming these limitations may enable the use of nanomaterials to resolve current infection control issues via application of nanomaterials as a platform for the diagnosis, prevention, and treatment of viral diseases.
冠状病毒病（COVID-19）大流行因新变种的不断出现而引发了严重的全球健康担忧。新型和再次出现的传染性病原体的周期性爆发增加了对未来的担忧和挑战。为了制定针对传染病的缓解策略，基于纳米的方法正越来越多地应用于诊断系统、预防性疫苗和治疗方法中。本综述介绍了各种纳米平台的特性，并讨论了它们在传感器、载体、递送剂、内在免疫刺激剂和病毒抑制剂开发中的作用。重点介绍了传染病的先进纳米医学应用。此外，还讨论了赋予生理优势并有助于控制和抑制传染病的物理化学性质。安全问题限制了这些技术在人类中的商业生产和临床应用；然而，克服这些限制可能会使纳米材料能够通过作为病毒疾病诊断、预防和治疗的平台来解决当前的感染控制问题。
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