Qi Guohua, Wang Bo, Song Xiangfu, Li Haijuan, Jin Yongdong
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Natl Sci Rev. 2020 Mar;7(3):660-670. doi: 10.1093/nsr/nwz199. Epub 2019 Dec 5.
By combined use of traditional Chinese acupuncture Fe needle electrode and electrochemistry, we achieved H generation in tumors in a controllable manner and exploited it for effective and green therapy of tumors for the first time. The cathodic acupuncture electrodes working under an applied voltage of ∼3 V (with minimal damage to the living body) undergo effective electrochemical reactions in the acidic tumor area that produce sufficient H locally to cause cancer cells to burst and die. Due to puncture positioning, the acidic tumor microenvironment and gas diffusion effect, the developed H generation electrochemotherapy (H-ECT) strategy enables precise and large-scale tumor therapy, as demonstrated by treatment of diseased mice (glioma and breast cancers). Such green H-ECT is simple, highly efficient and minimally invasive, requiring no expensive medical equipment or nano materials and medication, and is therefore very promising for potential clinical applications.
通过将传统中医毫针电极与电化学相结合，我们首次以可控方式在肿瘤中实现了氢气生成，并将其用于肿瘤的有效绿色治疗。在约3 V外加电压下工作的阴极针灸电极（对活体损伤最小）在酸性肿瘤区域发生有效的电化学反应，在局部产生足够的氢气，导致癌细胞破裂死亡。由于穿刺定位、酸性肿瘤微环境和气体扩散效应，所开发的氢气生成电化学疗法（H-ECT）策略能够实现精确且大规模的肿瘤治疗，对患病小鼠（胶质瘤和乳腺癌）的治疗证明了这一点。这种绿色的H-ECT简单、高效且微创，无需昂贵的医疗设备、纳米材料和药物，因此在潜在临床应用方面非常有前景。
