Ali Saiful, Haque Nasira, Azhar Zohya, Saeinasab Morvarid, Sefat Farshid
Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford BD7 1DP, UK.
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran.
Biomimetics (Basel). 2021 Oct 20;6(4):62. doi: 10.3390/biomimetics6040062.
Liver tissue engineering is a rapidly developing field which combines the novel use of liver cells, appropriate biochemical factors, and engineering principles, in order to replace or regenerate damaged liver tissue or the organ. The aim of this review paper is to critically investigate different possible methods to tackle issues related with liver diseases/disorders mainly using regenerative medicine. In this work the various regenerative treatment options are discussed, for improving the prognosis of chronic liver disorders. By reviewing existing literature, it is apparent that the current popular treatment option is liver transplantation, although the breakthroughs of stem cell-based therapy and bioartificial liver technology make them a promising alternative.
肝脏组织工程是一个快速发展的领域，它将肝细胞的新应用、适当的生化因子和工程原理结合起来，以替代或再生受损的肝脏组织或器官。这篇综述文章的目的是批判性地研究主要利用再生医学来解决与肝脏疾病/紊乱相关问题的不同可能方法。在这项工作中，讨论了各种再生治疗选择，以改善慢性肝脏疾病的预后。通过回顾现有文献，很明显目前流行的治疗选择是肝移植，尽管基于干细胞的疗法和生物人工肝技术的突破使它们成为有前景的替代方案。
