聚合物在实现基于 RNAi 的可持续害虫管理技术中的作用。

BioEcoUVA Research Institute on Bioeconomy, University of Valladolid, Valladolid, Spain.

Study, Preservation, and Recovery of Archaeological, Historical and Environmental Heritage (AHMAT), Condensed Matter Physics, Crystallography, and Mineralogy Department, Faculty of Science, University of Valladolid, Valladolid, Spain.

Nat Commun. 2024 Oct 23;15(1):9158. doi: 10.1038/s41467-024-53468-y.

The growing global food demand, coupled with the limitations of traditional pest control methods, has driven the search for innovative and sustainable solutions in agricultural pest management. In this review, we highlight polymeric nanocarriers for their potential to deliver double-stranded RNA (dsRNA) and control pests through the gene-silencing mechanism of RNA interference (RNAi). Polymer-dsRNA systems have shown promise in protecting dsRNA, facilitating cellular uptake, and ensuring precise release. Despite these advances, challenges such as scalability, cost-efficiency, regulatory approval, and public acceptance persist, necessitating further research to overcome these obstacles and fully unlock the potential of RNAi in sustainable agriculture.

随着全球对食物的需求不断增长，加之传统害虫防治方法的局限性，人们一直在寻找农业害虫管理方面的创新和可持续解决方案。在这篇综述中，我们重点介绍了聚合物纳米载体在通过 RNA 干扰（RNAi）的基因沉默机制传递双链 RNA（dsRNA）和控制害虫方面的潜力。聚合物-dsRNA 系统在保护 dsRNA、促进细胞摄取和确保精确释放方面显示出了前景。尽管取得了这些进展，但仍存在一些挑战，如可扩展性、成本效益、监管批准和公众接受度等，需要进一步研究来克服这些障碍，充分挖掘 RNAi 在可持续农业中的潜力。