Tashkandi Hanaa
Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Open Life Sci. 2021 Oct 6;16(1):1091-1100. doi: 10.1515/biol-2021-0084. eCollection 2021.
Wound healing is a complex process with many interdependent pathophysiological and immunological mediators to restore the cellular integrity of damaged tissue. Cutaneous wound healing is the repair response to a multitude of pathologies induced by trauma, surgery, and burn leading to the restoration and functionality of the compromised cells. Many different methods have been employed to treat acute and chronic wounds, such as antimicrobial therapy, as most wounds are susceptible to infection from microbes and are difficult to treat. However, many antimicrobial agents have become ineffective in wound treatment due to the emergence of multiple drug-resistant bacteria, and failures in current wound treatment methods have been widely reported. For this reason, alternative therapies have been sought, one of which is the use of honey as a wound treatment agent. The use of honey has recently gained clinical popularity for possible use in wound treatment and regenerative medicine. With this high demand, a better delivery and application procedure is required, as well as research aiming at its bioactivity. Honey is a safe natural substance, effective in the inhibition of bacterial growth and the treatment of a broad range of wound types, including burns, scratches, diabetic boils (Skin abscesses associated with diabetic), malignancies, leprosy, fistulas, leg ulcers, traumatic boils, cervical and varicose ulcers, amputation, burst abdominal wounds, septic and surgical wounds, cracked nipples, and wounds in the abdominal wall. Honey comprises a wide variety of active compounds, including flavonoids, phenolic acid, organic acids, enzymes, and vitamins, that may act to improve the wound healing process. Tissue-engineered scaffolds have recently attracted a great deal of attention, and various scaffold fabrication techniques are being researched. Some incorporate honey to improve their delivery during wound treatment. Hence, the aim of this review is to summarize recent studies on the wound healing properties of honey.
伤口愈合是一个复杂的过程，有许多相互依存的病理生理和免疫介质来恢复受损组织的细胞完整性。皮肤伤口愈合是对由创伤、手术和烧伤引起的多种病理状况的修复反应，从而恢复受损细胞的功能。已经采用了许多不同的方法来治疗急性和慢性伤口，比如抗菌疗法，因为大多数伤口容易受到微生物感染且难以治疗。然而，由于多重耐药菌的出现，许多抗菌剂在伤口治疗中已变得无效，并且当前伤口治疗方法的失败情况已被广泛报道。因此，人们一直在寻求替代疗法，其中之一就是使用蜂蜜作为伤口治疗剂。蜂蜜在伤口治疗和再生医学中的潜在应用最近在临床上受到了欢迎。鉴于这种高需求，需要更好的递送和应用程序，以及针对其生物活性的研究。蜂蜜是一种安全的天然物质，能有效抑制细菌生长并治疗多种伤口类型，包括烧伤、擦伤、糖尿病性疖肿（与糖尿病相关的皮肤脓肿）、恶性肿瘤、麻风病、瘘管、腿部溃疡、创伤性疖肿、宫颈和静脉曲张溃疡、截肢伤口、腹部爆裂伤口、脓毒性和手术伤口、乳头皲裂以及腹壁伤口。蜂蜜包含多种活性化合物，包括黄酮类化合物、酚酸类化合物、有机酸、酶和维生素，这些可能有助于改善伤口愈合过程。组织工程支架最近引起了广泛关注，并且正在研究各种支架制造技术。一些支架加入了蜂蜜以改善其在伤口治疗期间的递送效果。因此，本综述的目的是总结近期关于蜂蜜伤口愈合特性的研究。
