Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Hum Brain Mapp. 2022 Feb 1;43(2):816-832. doi: 10.1002/hbm.25690. Epub 2021 Oct 28.
The UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self-report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS-4) score which we recommend for state-dependent and longitudinal research in the UKB. We furthermore tested univariate and multivariate associations between brain imaging-derived phenotypes (IDPs) and mental health. Our results showed a significant multivariate relationship between IDPs and mental health, which was replicable. Conversely, effect sizes for individual IDPs were small. Test-retest reliability of IDPs was stronger for measures of brain structure than for measures of brain function. Taken together, these results provide benchmarks and guidelines for future UKB research into brain biomarkers of mental health.
英国生物银行（UKB）是一个极具前景的数据集，可用于研究人口心理健康的大脑生物标志物，这要归功于其空前的样本量以及广泛的表型、影像和生物学测量。在这项研究中，我们旨在为 UKB 神经影像学研究精神健康提供一个共享的基础，重点关注焦虑和抑郁。我们比较了 UKB 的自我报告测量，并揭示了扫描采集和一些心理健康测量的在线单独采集之间的重要时间效应。为了克服这些时间效应，我们引入并验证了最近抑郁症状（RDS-4）评分，我们建议在 UKB 中进行状态相关和纵向研究时使用该评分。我们还测试了基于大脑影像的表型（IDP）和心理健康之间的单变量和多变量关联。我们的结果显示，IDP 和心理健康之间存在显著的多变量关系，并且可以复制。相反，个体 IDP 的效应大小很小。IDP 的测试 - 重测信度对于脑结构测量比脑功能测量更强。总的来说，这些结果为未来 UKB 研究精神健康的大脑生物标志物提供了基准和指导。
