患病率的Meta分析:COVID-19幸存者的心理后遗症

Meta-analysis of prevalence: the psychological sequelae among COVID-19 survivors.

作者信息

Khraisat Bann, Toubasi Ahmad, AlZoubi Lujain, Al-Sayegh Thuraya, Mansour Ahmad

机构信息

Faculty of Medicine, The University of Jordan, Amman, Jordan.

Department of Pathology, University of Cincinnati, Cincinnati, OH, USA.

出版信息

Int J Psychiatry Clin Pract. 2022 Sep;26(3):234-243. doi: 10.1080/13651501.2021.1993924. Epub 2021 Oct 28.

Abstract

OBJECTIVE

This meta-analysis aims to estimate the pooled prevalence of mental disorders among COVID-19 survivors.

METHODS

The databases Pubmed, Google Scholar, ScienceDirect, and medRxiv have been searched up to 1 August 2021 using COVID-19, survivors, mental disorders, and their related MeSH terms. The included studies were either cross-sectional, cohort, or case-control in design. Those studies included COVID-19 survivors after 14 or more days from their COVID-19 recovery and used validated questionnaires to assess their mental health outcomes. The random-effects model was used to pool the data from the incorporated studies. The heterogeneity was assessed using Cochran's heterogeneity test and statistic.

RESULTS

Twenty-seven studies were included in the data synthesis with a total sample size of 9605 COVID-19 survivors. The prevalence rates for Post-Traumatic Stress Disorder (PTSD), anxiety, psychological distress, depression, and sleeping disorders were 20% (95% CI = 16-24%), 22% (95% CI = 18-27%), 36% (95% CI = 22-51%), 21% (95% CI = 16-28%), and 35% (95% CI = 29-41%), respectively.

CONCLUSIONS

Although we found high heterogeneity across the included studies, our meta-analysis provides evidence that there are psychological sequelae in COVID-19 survivors that require medical assiduity as well as further research on the matter.KEY POINTSIncreased prevalence of psychological sequelae among COVID-19 survivors.The prevalence of PTSD was 20% (95% CI = 16-24%) and of anxiety was 22% (95% CI = 18-27%) among COVID-19 survivors.The prevalence of psychological distress was 36% (95% CI = 22-51%), of depression was 21% (95% CI = 16-28%), and of sleep disorders was 35% (95% CI = 29-41%) among COVID-19 survivors.Future researches are recommended to search for effective and safe methods to mitigate the psychological sequelae in COVID-19 patients.

摘要

目的

本荟萃分析旨在估计新冠病毒疾病(COVID-19)幸存者中精神障碍的合并患病率。

方法

截至2021年8月1日,使用“COVID-19”“幸存者”“精神障碍”及其相关医学主题词(MeSH)检索了PubMed、谷歌学术、ScienceDirect和medRxiv数据库。纳入的研究设计为横断面研究、队列研究或病例对照研究。这些研究纳入了COVID-19康复后14天或更长时间的COVID-19幸存者,并使用经过验证的问卷来评估他们的心理健康结果。采用随机效应模型汇总纳入研究的数据。使用Cochran异质性检验和统计量评估异质性。

结果

27项研究纳入数据综合分析,样本总量为9605名COVID-19幸存者。创伤后应激障碍(PTSD)、焦虑、心理困扰、抑郁和睡眠障碍的患病率分别为20%(95%置信区间=16%-24%)、22%(95%置信区间=18%-27%)、36%(95%置信区间=22%-51%)、21%(95%置信区间=16%-28%)和35%(95%置信区间=29%-41%)。

结论

尽管我们发现纳入的研究存在高度异质性,但我们的荟萃分析提供了证据,表明COVID-19幸存者存在心理后遗症,这需要医疗关注以及对此问题的进一步研究。要点COVID-19幸存者心理后遗症患病率增加。COVID-19幸存者中PTSD患病率为20%(95%置信区间=16%-24%),焦虑患病率为22%(95%置信区间=18%-27%)。COVID-19幸存者中,心理困扰患病率为36%(95%置信区间=22%-51%),抑郁患病率为21%(95%置信区间=16%-28%),睡眠障碍患病率为35%(95%置信区间=29%-41%)。建议未来的研究寻找有效且安全的方法来减轻COVID-19患者的心理后遗症。

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