Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States of America.
PLoS One. 2021 Oct 28;16(10):e0259143. doi: 10.1371/journal.pone.0259143. eCollection 2021.
This study investigated the agreement of intraocular pressure measurements using rebound tonometry and applanation tonometry in response to atmospheric changes in a hyperbaric chamber. Twelve eyes of 12 healthy subjects were included in this prospective, comparative, single-masked study. Intraocular pressure measurements were performed by rebound tonometry followed by applanation tonometry in a multiplace hyperbaric chamber at 1 Bar, followed by 2, 3 and 4 Bar during compression and again at 3 and 2 Bar during decompression. Mean differences between rebound and applanation intraocular pressure measurements were 1.6, 1.7, and 2.1 mmHg at 2, 3, and 4 Bar respectively during compression and 2.6 and 2.2 mmHg at 3 and 2 Bar during decompression. Lower limits of agreement ranged from -3.7 to -5.9 mmHg and upper limits ranged from -0.3 to 1.9 mmHg. Multivariate analysis showed that the differences between rebound and applanation intraocular pressure measurements were independent of atmospheric pressure changes (p = 0.79). Intraocular pressure measured by rebound tonometry shows a systematic difference compared to intraocular measured by applanation tonometry, but this difference is not influenced by changes of atmospheric pressure up to 4 Bar in a hyperbaric chamber. Agreement in magnitude of change between devices suggests rebound tonometry is viable for assessing intraocular pressure during atmospheric changes. Future studies should be designed in consideration of expected differences in IOP values provided by the two devices.
本研究旨在探讨在高压舱内大气压力变化时，回弹眼压测量与压平眼压测量的一致性。本前瞻性、对比、单盲研究纳入了 12 名健康受试者的 12 只眼。在 1 巴的多床位高压舱中，首先使用回弹眼压计进行眼压测量，然后使用压平眼压计进行眼压测量，接着在压缩过程中分别在 2、3 和 4 巴下，以及在减压过程中在 3 和 2 巴下再次进行眼压测量。在压缩过程中，回弹眼压计和压平眼压计测量的眼压平均值差异分别为 2 巴时 1.6mmHg、3 巴时 1.7mmHg 和 4 巴时 2.1mmHg，在减压过程中分别为 3 巴时 2.6mmHg 和 2 巴时 2.2mmHg。差异的下限范围为-3.7 至-5.9mmHg，上限范围为-0.3 至 1.9mmHg。多变量分析表明，回弹眼压计和压平眼压计测量的眼压差异不受大气压力变化的影响（p=0.79）。回弹眼压计测量的眼压与压平眼压计测量的眼压相比存在系统差异，但这种差异不受高压舱内大气压变化至 4 巴的影响。两种设备之间眼压变化幅度的一致性表明，回弹眼压计在大气压力变化期间评估眼压是可行的。未来的研究应考虑到两种设备提供的眼压值的预期差异进行设计。
