Gou Chunyan, Zhang Yuting, Nie Guohui, He Yonghong, Guan Tian
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong 518055, P.R.China.
Department of Biomedical Engineering, Tsinghua University, Beijing 100084, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Oct 25;38(5):1018-1027. doi: 10.7507/1001-5515.202104066.
Spinal fusion is a standard operation for treating moderate and severe intervertebral disc diseases. In recent years, the proportion of three-dimensional printing interbody fusion cage in spinal fusion surgery has gradually increased. In this paper, the research progress of molding technology and materials used in three-dimensional printing interbody fusion cage at present is summarized. Then, according to structure layout, three-dimensional printing interbody fusion cages are classified into five types: solid-porous-solid (SPS) type, solid-porous-frame (SPF) type, frame-porous-frame (FPF) type, whole porous cage (WPC) type and others. The optimization process of three-dimensional printing interbody fusion cage and the advantages and disadvantages of each type are analyzed and summarized in depth. The clinical application of various types of 3D printed interbody fusion cage was introduced and summarized later. Lastly, combined with the latest research progress and achievements, the future research direction of three-dimensional printing interbody fusion cage in molding technology, application materials and coating materials is prospected in order to provide some reference for scholars engaged in interbody fusion cage research and application.
脊柱融合术是治疗中重度椎间盘疾病的标准手术。近年来，三维打印椎间融合器在脊柱融合手术中的应用比例逐渐增加。本文总结了目前三维打印椎间融合器所使用的成型技术和材料的研究进展。然后，根据结构布局，将三维打印椎间融合器分为五种类型：实心-多孔-实心（SPS）型、实心-多孔-框架（SPF）型、框架-多孔-框架（FPF）型、全多孔笼（WPC）型及其他类型。深入分析并总结了三维打印椎间融合器的优化过程以及每种类型的优缺点。随后介绍并总结了各类3D打印椎间融合器的临床应用情况。最后，结合最新的研究进展和成果，对三维打印椎间融合器在成型技术、应用材料和涂层材料方面的未来研究方向进行了展望，以期为从事椎间融合器研究与应用的学者提供一些参考。
