Department of Internal Medicine, Chonnam National University Medical School, and Chonnam National University Hospital, Gwangju, Korea.
Department of Statistics and Actuarial Science, The Soongsil University of Korea, Seoul, Korea.
Medicine (Baltimore). 2021 Oct 29;100(43):e27628. doi: 10.1097/MD.0000000000027628.
Retinal vein occlusion (RVO) is an important cause of blindness. Hypertension is a well-known risk factor for RVO. Although the prevalence of hypertension increases in women after menopause, the relationship between blood pressure and RVO in women before and after menopause has not been studied in detail.We retrospectively analyzed 2,619,206 patients from the Korean National Health Insurance System database. A Cox proportional hazard regression model was used to evaluate the independent association between blood pressure and the risk of RVO development and identify differences between premenopausal and postmenopausal women.The incidence of RVO was higher among postmenopausal women than in premenopausal women. In the model adjusted for socioeconomic and clinical variables, there was an association between blood pressure and RVO development in premenopausal and postmenopausal women; however, this was stronger than premenopausal women.Both systolic and diastolic blood pressure are associated with an increased risk of RVO, and their effects are more potent in premenopausal women than postmenopausal women. Thus, comprehensive management of hypertension in premenopausal women is essential to reduce the risk of RVO.
视网膜静脉阻塞 (RVO) 是失明的一个重要原因。高血压是 RVO 的一个已知危险因素。虽然女性绝经后高血压的患病率增加，但绝经前后女性血压与 RVO 之间的关系尚未详细研究。我们回顾性分析了来自韩国国家健康保险系统数据库的 2,619,206 名患者。使用 Cox 比例风险回归模型评估血压与 RVO 发展风险之间的独立关联，并确定绝经前和绝经后妇女之间的差异。与绝经前妇女相比，绝经后妇女的 RVO 发病率更高。在调整了社会经济和临床变量的模型中，血压与绝经前和绝经后妇女的 RVO 发展之间存在关联；然而，这种关联在绝经前妇女中更强。收缩压和舒张压均与 RVO 风险增加相关，其在绝经前妇女中的作用强于绝经后妇女。因此，绝经前妇女的高血压综合管理对于降低 RVO 风险至关重要。
