Department of Neurosurgery, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
Department of Medical Oncology, School for Oncology and Developmental Biology (GROW), Maastricht UMC+, Maastricht, The Netherlands.
Acta Neurochir (Wien). 2022 Feb;164(2):423-427. doi: 10.1007/s00701-021-05035-3. Epub 2021 Oct 29.
Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.
副肿瘤神经系统综合征（PNS）可表现为各种类型的恶性肿瘤。一种众所周知的综合征是重症肌无力（MG）合并胸腺瘤。尚未描述原发性脑肿瘤与神经肌肉疾病之间的关联。在这里，我们报告了一例 65 岁患者的病例，该患者在无脑膜瘤全切术后出现 MG。据我们所知，这是首例描述脑膜瘤切除术后早期发生 MG 的病例。当神经系统综合征在恶性肿瘤发生时或其后不久被诊断时，目前的 PNS 标准是不充分的，应该重新考虑。
