Department of General Surgery, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, 130041, China.
Operating Theater and Department of Anestheology, The Second Hospital of Jilin University, Changchun, 130041, China.
Stem Cell Res Ther. 2021 Oct 30;12(1):561. doi: 10.1186/s13287-021-02629-7.
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding a suitable drug delivery carrier in the body has become a popular research today. In various drug delivery studies, the exosomes secreted by mesenchymal stem cells (MSC-EXOs) have been broadly researched due to their immune properties, tumor-homing properties, and elastic properties. While MSC-EXOs have apparent advantages, some unresolved problems also exist. This article reviews the studies on MSC-EXOs for drug delivery, summarizes the characteristics of MSC-EXOs, and introduces the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.
外泌体是由各种细胞分泌的细胞外囊泡，主要由无细胞器的脂质双层组成。近年来，越来越多的研究人员关注将外泌体用于药物递送。在体内进行靶向药物递送是治疗肿瘤和阿尔茨海默病（AD）等许多难治性疾病的有前途的方法。在体内寻找合适的药物递送载体已成为当今热门的研究领域。在各种药物递送研究中，由于间充质干细胞（MSC-EXOs）分泌的外泌体具有免疫特性、肿瘤归巢特性和弹性特性，因此受到广泛研究。虽然 MSC-EXOs 具有明显的优势，但也存在一些尚未解决的问题。本文综述了用于药物递送的 MSC-EXOs 的研究，总结了 MSC-EXOs 的特性，介绍了主要的生产和纯化方法以及药物加载方法，为现有问题提供了解决方案，并对未来的研究提出了建议。
