Bowers R W, Tighe B J
Biomaterials. 1987 Mar;8(2):89-93. doi: 10.1016/0142-9612(87)90095-0.
Light and scanning electron microscopical techniques have been employed to determine the morphology, geographical location and incidence of occurrence of discrete elevated deposits on a variety of commercial lenses of differing bulk and surface chemistries and also wear protocols. Spoilt lenses were derived from controlled lens wear trials and additional clinical sources. This type of elevated deposit displays a complex morphology and is composed of three distinctive yet interactive sub-layers. It is apparent that alterations in lens surface properties, wear protocol, and application of the device are not significant in determining deposit morphology. The rate of deposit formation is however, a function of the lens chemistry, wear protocol and the individual patient. These findings promote the belief that some common biological interface conversion event, or events, occur which reduce the biocompatibility of these materials with their ocular environment.
已采用光学和扫描电子显微镜技术来确定在各种具有不同体积和表面化学性质以及佩戴方案的商业镜片上离散隆起沉积物的形态、地理位置和出现频率。损坏的镜片来自受控的镜片佩戴试验和其他临床来源。这种类型的隆起沉积物呈现出复杂的形态，由三个独特但相互作用的子层组成。显然，镜片表面性质、佩戴方案和器械应用的改变在决定沉积物形态方面并不显著。然而，沉积物形成的速率是镜片化学性质、佩戴方案和个体患者的函数。这些发现促使人们相信发生了一些常见的生物界面转化事件，这些事件降低了这些材料与眼部环境的生物相容性。
