Contipro a.s., Dolní Dobrouč, Czech Republic.
Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Exp Dermatol. 2022 Apr;31(4):442-458. doi: 10.1111/exd.14491. Epub 2021 Nov 15.
Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water-retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation-triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.
光老化皮肤表现出炎症、DNA 损伤和形态变化的迹象，这些在宏观和微观水平上都是可见的。光老化还会影响细胞外基质 (ECM)，包括透明质酸 (HA)，其主要多糖成分。HA 是一种结构简单但生物学复杂的分子，它作为一种保持水分的成分，为 ECM 的许多蛋白质提供支架，并为细胞受体的配体。本研究综述了有关 HA 数量、大小和代谢变化的文献，并探讨了 HA 在光老化中的潜在作用。此外，我们还根据 HA 在其他病理过程中的作用，包括衰老和炎症触发的 ECM 重组，提出了 HA 对光老化的新贡献。最后，我们还讨论了潜在的直接或间接干预措施，以减轻光老化，包括针对透明质酸代谢的干预措施以及补充。
