血小板细胞外囊泡在 COVID-19 中的作用：潜在的标志物和制造者。
Platelet extracellular vesicles in COVID-19: Potential markers and makers.
机构信息
Department of Infectious Diseases and Immunity, Centre de recherche du CHU de Québec, Québec, Québec, Canada.
Université Laval and Centre de recherche ARThrite, Québec, Québec, Canada.
出版信息
J Leukoc Biol. 2022 Jan;111(1):63-74. doi: 10.1002/JLB.3MIR0221-100R. Epub 2021 Nov 3.
Abstract
Platelets and platelet extracellular vesicles (pEV) are at the crossroads of coagulation and immunity. Extracellular vesicles are messengers that not only transmit signals between cells, but also provide information about the status of their cell of origin. Thus, pEVs have potential as both biomarkers of platelet activation and contributors to pathology. Coronavirus Disease-19 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a complex disease affecting multiple organs and is characterized by a high degree of inflammation and risk of thrombosis in some patients. In this review, we introduce pEVs as valuable biomarkers in disease with a special focus on their potential as predictors of and contributors to COVID-19.
摘要
血小板和血小板细胞外囊泡（pEV）处于凝血和免疫的交汇点。细胞外囊泡不仅在细胞之间传递信号，还提供有关其起源细胞状态的信息。因此，pEV 具有作为血小板活化的生物标志物和病理贡献者的双重潜力。由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）感染引起的冠状病毒病 19（COVID-19）是一种影响多个器官的复杂疾病，其特征是在一些患者中存在高度炎症和血栓形成的风险。在这篇综述中，我们将 pEV 作为疾病的有价值的生物标志物进行介绍，特别关注它们作为 COVID-19 的预测因子和贡献者的潜力。
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