Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, P.O Box 8340, Yaoundé, Cameroon.
Yaoundé Jamot Hospital, Yaoundé, Cameroon.
BMC Pulm Med. 2021 Nov 3;21(1):344. doi: 10.1186/s12890-021-01705-1.
Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative spirometric equations from a representative population of Cameroonian children and adults and compare these equations with those developed by the Global Lung Initiative (GLI) and in Nigerians.
Spirometric data from healthy Cameroonians aged 4-89 years randomly collected between 2014 and 2018 were used to derive reference equations using generalized additive model for location (mu), shape (lambda) and scale (sigma).
A total of 625 children and adolescents (290 males and 335 females) and 1152 adults (552 males and 600 females) were included in the study. The prediction equation for spirometric index was written as: M = Exp[a0 + a1ln (Height) + a2ln (Age) + Mspline, Mspline was age related spline contribution]. Applying the GLI standards for African Americans resulted in overall values greater than those found in our study for forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC). These values were very close in children and adolescents while the values obtained with the GLI equations for African Americans were significantly higher in adults. FEV1/FVC ratio in our study was similar for adult males but lower in adult females (88% vs 85%, difference = + 3.5%) when applying Nigerian standards.
FEV1 and FVC of the Cameroonian infant and adolescent population are very close to those of black Americans. However, FEV1 and FVC of Cameroonian adults are significantly lower than those of black American adults. These equations should allow a more suitable interpretation of spirometry in the Cameroonian population.
几种族裔的人群中都有熟知的肺量测定参考值，但关于生活在非洲的黑人的规范肺量测定值的研究则较少。本研究的目的是建立喀麦隆儿童和成人的规范肺量测定方程，并与全球肺倡议（GLI）和尼日利亚建立的方程进行比较。
使用广义加性模型对位置（mu）、形状（lambda）和比例（sigma）进行位置（mu）、形状（lambda）和比例（sigma）分析，分析了 2014 年至 2018 年间随机收集的健康喀麦隆人的肺量测定数据，以得出参考方程。
共有 625 名儿童和青少年（290 名男性和 335 名女性）和 1152 名成年人（552 名男性和 600 名女性）纳入研究。肺量测定指数的预测方程为：M = Exp[a0 + a1ln（身高）+ a2ln（年龄）+ Mspline，Mspline 为与年龄相关的样条贡献]。应用 GLI 标准对非裔美国人进行评估，得出的用力呼气量 1 秒（FEV1）和用力肺活量（FVC）值均大于本研究发现的值。这些值在儿童和青少年中非常接近，而应用 GLI 方程为非裔美国人得出的数值在成年人中显著更高。本研究中，男性成年人的 FEV1/FVC 比值相似，但女性成年人的 FEV1/FVC 比值较低（88%对 85%，差值=+3.5%），当应用尼日利亚标准时。
喀麦隆婴幼儿人群的 FEV1 和 FVC 与非裔美国人非常接近。然而，喀麦隆成年人的 FEV1 和 FVC 明显低于非裔美国成年人。这些方程应能更适当地解释喀麦隆人群的肺量测定。
