Endicott-Yazdani Tiana R, Schwartz Gary S, Zhang Haiying, Rosenblatt Randall L, Garcha Puneet S
Department of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, Texas.
Department of Cardiothoracic Surgery, Baylor University Medical Center, Dallas, Texas.
Proc (Bayl Univ Med Cent). 2021 Aug 18;34(6):731-733. doi: 10.1080/08998280.2021.1953884. eCollection 2021.
Pulmonary alveolar proteinosis is an uncommon cause of insidious onset shortness of breath and hypoxemia. It is caused by an accumulation of surfactant within the alveoli. Left untreated, it can be fatal. Standard-of-care treatment is whole-lung lavage; however, in severe cases, the associated hypoxemia can be profound and single-lung ventilation would not be tolerated, potentially preventing a lifesaving treatment. Single cases using veno-venous extracorporeal membrane oxygenation to perform whole-lung lavage have been reported. Here we describe three patients with severe pulmonary alveolar proteinosis who were successfully treated with whole-lung lavage using veno-venous extracorporeal membrane oxygenation for oxygenation support.
肺泡蛋白沉积症是隐匿性起病的呼吸急促和低氧血症的罕见病因。它是由肺泡内表面活性物质积聚所致。若不治疗，可能会致命。标准治疗方法是全肺灌洗；然而，在严重病例中，相关的低氧血症可能很严重，无法耐受单肺通气，这可能会妨碍这种挽救生命的治疗。已有使用静脉 - 静脉体外膜肺氧合进行全肺灌洗的单例报道。在此，我们描述了三名严重肺泡蛋白沉积症患者，他们通过使用静脉 - 静脉体外膜肺氧合进行氧合支持成功接受了全肺灌洗治疗。
