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新冠病毒感染人群中的神经学表现:简要综述

Neurological Manifestations in COVID-19 Population: A Short Review.

作者信息

Singh Kamal Pratap, Agarwal Rachna

机构信息

Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, Delhi, India.

出版信息

Ann Neurosci. 2021 Jan;28(1-2):94-100. doi: 10.1177/0972753121990247. Epub 2021 May 7.

Abstract

BACKGROUND

Coronaviruses (CoVs) have a neuroinvasive potential, which has been discussed in various research papers. During the current pandemic, the novel CoV, i.e., SARS-CoV-2, is causing a considerable number of fatalities and posing a great danger of a recurrent epidemic. COVID-19 has been labeled as a public health emergency of international concern, and the epidemic curves are on the rise.

PURPOSE

Some studies discuss the neurological implications of SARS-CoV-2 but in light of growing number of evidences we cannot ignore the planning of mental health care settings in COVID-19. We are discussing how this novel CoV can affect the human brain directly and indirectly, including psychiatric problems, and how neurological conditions can be explored as a diagnostic tool in COVID-19 by analyzing cohort studies and review papers that discuss the recent neurological findings in COVID-19.

METHOD

Current research and review papers were searched to find out any relation between the COVID-19 disease and the altered mental health. This study attempts to find out neurological symptoms in a large population affected by COVID-19 and thus filtering out individual case reports and cohort studies which have a patient pool of less than 50.

RESULTS

This unique observation revealed that SARS-CoV-2 has direct neurological manifestations such as anosmia and gustatory impairment, encephalopathy, and seizures as well as an indirect effect on the psychiatric health such as anxiety, amnesia, etc. because of psychosocial stress.

CONCLUSION

The most commonly reported neurological symptoms should not be ignored and must be tested for COVID-19. More neurological studies like medical imaging and neuropathology should be performed on these COVID-19 patients.

摘要

背景

冠状病毒(CoVs)具有神经侵袭潜力,这在各种研究论文中已有讨论。在当前的大流行期间,新型冠状病毒,即严重急性呼吸综合征冠状病毒2(SARS-CoV-2),正在导致大量死亡,并构成再次流行的巨大危险。2019冠状病毒病(COVID-19)已被列为国际关注的突发公共卫生事件,疫情曲线呈上升趋势。

目的

一些研究讨论了SARS-CoV-2的神经学影响,但鉴于越来越多的证据,我们不能忽视COVID-19心理健康护理环境的规划。我们正在讨论这种新型冠状病毒如何直接和间接影响人类大脑,包括精神问题,以及如何通过分析队列研究和综述论文来探索神经学状况作为COVID-19的诊断工具,这些论文讨论了COVID-19最近的神经学发现。

方法

检索当前的研究和综述论文,以找出COVID-19疾病与心理健康改变之间的任何关系。本研究试图在受COVID-19影响的大量人群中找出神经症状,从而筛选出患者群体少于50人的个别病例报告和队列研究。

结果

这一独特的观察结果表明,SARS-CoV-2具有直接的神经学表现,如嗅觉丧失和味觉障碍、脑病和癫痫发作,以及由于心理社会压力对心理健康产生的间接影响,如焦虑、失忆等。

结论

最常报告的神经症状不应被忽视,必须对COVID-19进行检测。应该对这些COVID-19患者进行更多的神经学研究,如医学成像和神经病理学研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178b/8558982/188f5d9f1666/10.1177_0972753121990247-fig1.jpg

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Neuropsychiatric aspects of COVID-19 pandemic: A selective review.新冠疫情期间的神经精神学方面:选择性综述。
Asian J Psychiatr. 2020 Oct;53:102188. doi: 10.1016/j.ajp.2020.102188. Epub 2020 May 30.
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Respiratory Virus Infections: Understanding COVID-19.呼吸道病毒感染:了解 COVID-19。
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