College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, No. 1, Qianjiang Road, Hefei City, Anhui Province, China.
Institutes of Integrative Medicine, Fudan University, Shanghai, China.
Mediators Inflamm. 2021 Oct 25;2021:2689600. doi: 10.1155/2021/2689600. eCollection 2021.
Chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, is characterized by the alveolar epithelium injury and persistent airway inflammation. It is documented that oscillation and dysregulated expression of circadian clock genes, like Bmal1, Per1, and Per2, involved in COPD pathogenies, including chronic inflammation and imbalanced autophagy level, and targeting the associations of circadian rhythm and autophagy is promising strategies in the management and treatment of COPD. Herein, we reviewed the mechanisms of the circadian clock and the unbalance of the autophagic level in COPD, as well as the link between the two, so as to provide further theoretical bases for the study on the pathogenesis of COPD.
慢性阻塞性肺疾病（COPD）是一种进行性呼吸系统疾病，其特征是肺泡上皮损伤和持续的气道炎症。有文献表明，生物钟基因（如 Bmal1、Per1 和 Per2）的振荡和失调表达与 COPD 的发病机制有关，包括慢性炎症和自噬水平失衡，针对生物钟节律和自噬之间的关联是 COPD 管理和治疗的有前途的策略。在此，我们综述了生物钟的机制和 COPD 中自噬水平的失衡，以及两者之间的联系，为 COPD 发病机制的研究提供了进一步的理论基础。
