Nejabat Masoud, Samie Ali, Khojastehnezhad Amir, Hadizadeh Farzin, Ramezani Mohammad, Alibolandi Mona, Abnous Khalil, Taghdisi Seyed Mohammad, Siaj Mohamed
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91388-13944, Iran.
Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91388-13944, Iran.
ACS Appl Mater Interfaces. 2024 Oct 2;16(39):51837-51859. doi: 10.1021/acsami.4c07040. Epub 2024 Aug 20.
Chemotherapy as a common anticancer therapeutic modality is often challenged by various obstacles such as poor stability, low solubility, and severe side effects of chemotherapeutic agents as well as multidrug resistance of cancerous cells. Nanoparticles in the role of carriers for chemotherapeutic drugs and platforms for combining different therapeutic approaches have effectively participated in overcoming such drawbacks. In particular, nanoparticles able to induce their therapeutic effect in response to specific stimuli like tumor microenvironment characteristics (e.g., hypoxia, acidic pH, high levels of glutathione, and overexpressed hydrogen peroxide) or extrinsic stimulus of laser light bring about more precise and selective treatments. Among them, nanostructures of covalent organic frameworks (COFs) have drawn great interest in biomedical fields during recent years. Possessing large surface area, high porosity, structural stability, and customizable architecture, these biocompatible porous crystalline polymers properly translate to promising platforms for drug delivery and induction of combination therapies. With the focus on stimuli-responsive characteristics of nanoscale COFs, this study aims to propose an overview of their potentiality in cancer treatment on the basis of chemotherapy alone or in combination with sonodynamic, chemodynamic, photodynamic, and photothermal therapies.
化疗作为一种常见的抗癌治疗方式，常常受到各种障碍的挑战，如化疗药物稳定性差、溶解度低、副作用严重以及癌细胞的多药耐药性。纳米颗粒作为化疗药物的载体以及结合不同治疗方法的平台，有效地参与克服了这些缺点。特别是，能够响应特定刺激（如肿瘤微环境特征，如缺氧、酸性pH值、高浓度谷胱甘肽和过氧化氢过表达）或外部激光刺激而产生治疗效果的纳米颗粒，能带来更精确和选择性的治疗。其中，共价有机框架（COF）的纳米结构近年来在生物医学领域引起了极大的关注。这些生物相容性多孔结晶聚合物具有大表面积、高孔隙率、结构稳定性和可定制结构，非常适合作为药物递送和联合治疗诱导的有前景的平台。基于纳米级COF的刺激响应特性，本研究旨在概述其在单独化疗或与声动力、化学动力、光动力和光热疗法联合使用时在癌症治疗中的潜力。
