Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Shriners Hospitals for Children - Saint Louis, St. Louis, MO, 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Shriners Hospitals for Children - Saint Louis, St. Louis, MO, 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, 63105, USA.
Curr Opin Biotechnol. 2022 Feb;73:374-379. doi: 10.1016/j.copbio.2021.09.011. Epub 2021 Nov 1.
'Mechanogenetics,' a new field at the convergence of mechanobiology and synthetic biology, presents an innovative strategy to treat, repair, or restore diseased cells and tissues by harnessing mechanical signal transduction pathways to control gene expression. While the role of mechanical forces in regulating development, homeostasis, and disease is well established, only recently have we identified the specific mechanosensors and downstream signaling pathways involved in these processes. Simultaneously, synthetic biological systems are developing increasingly sophisticated approaches of controlling mammalian cellular responses. Continued mechanistic refinement and identification of how cellular mechanosensors respond to homeostatic and pathological mechanical forces, combined with synthetic tools to integrate and respond to these inputs, promises to extend the development of new therapeutic approaches for treating disease.
“机械基因学”是力学生物学和合成生物学交叉领域的一个新兴领域，它提出了一种创新策略，通过利用机械信号转导途径来控制基因表达，从而治疗、修复或恢复患病细胞和组织。虽然机械力在调节发育、稳态和疾病中的作用已得到充分证实，但直到最近我们才确定了参与这些过程的特定机械感受器和下游信号通路。与此同时，合成生物学系统正在开发越来越复杂的控制哺乳动物细胞反应的方法。不断深入的机械学研究和对细胞机械感受器如何响应稳态和病理机械力的研究，结合整合和响应这些输入的合成工具，有望为治疗疾病的新治疗方法的发展提供帮助。
