猪戊型肝炎病毒感染：来自赞比亚的首次报告。
Hepatitis E virus infection in pigs: a first report from Zambia.
机构信息
Division of Molecular Pathobiology, International Institute for Zoonosis Control, Sapporo, Japan.
Virology Laboratory, Central Veterinary Research Institute, Lusaka, Zambia.
出版信息
Emerg Microbes Infect. 2021 Dec;10(1):2169-2172. doi: 10.1080/22221751.2021.2002669.
While evidence suggests presence of HEV infection in humans in Zambia, currently, there is no information on its occurrence in domestic pigs. Here, we investigated the presence of HEV antibodies and genome in domestic pigs in Zambia. Sera ( = 484) from domestic pigs were screened for antibodies against HEV by ELISA while genome detection in fecal ( = 25) and liver ( = 100) samples from slaughter pigs was conducted using nested RT-PCR assay. Overall, seroprevalence was 47.7% (231/484) while zoonotic genotype 3 HEV RNA was detected in 16.0% (20/125) of slaughtered pigs. This is the first report to highlight occurrence of HEV infection in domestic pigs in Zambia. This finding suggests possible contamination of the pork supply chain. Moreover, there is a potential risk of zoonotic transmission of HEV to abattoir workers, pig farmers and handlers.
虽然有证据表明赞比亚人体内存在戊型肝炎病毒（HEV）感染，但目前尚无有关其在家猪中发生的信息。在这里，我们调查了赞比亚家猪中 HEV 抗体和基因组的存在情况。通过酶联免疫吸附试验（ELISA）检测了来自家猪的血清（ = 484）中针对 HEV 的抗体，而使用巢式 RT-PCR 检测了来自屠宰猪的粪便（ = 25）和肝脏（ = 100）样本中的基因组。总体而言，血清阳性率为 47.7%（231/484），而在 16.0%（20/125）的屠宰猪中检测到了人畜共患基因型 3 HEV RNA。这是首次报告在赞比亚的家猪中发生 HEV 感染。这一发现表明猪肉供应链可能受到污染。此外，戊型肝炎病毒可能会在家畜屠宰工人、养猪户和处理者之间发生人畜共患传播的风险。
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