从泰国大米中分离得到的内生真菌的细胞毒性和抗菌去甲二萜。

Cytotoxic and antibacterial depsidones from the endophytic fungus isolated from Thai rice.

机构信息

Faculty of Science, Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand.

Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.

出版信息

Nat Prod Res. 2022 Sep;36(18):4605-4613. doi: 10.1080/14786419.2021.1999947. Epub 2021 Nov 5.

DOI:10.1080/14786419.2021.1999947

PMID:34736358

Abstract

Four new depsidones, mollicellins V-Y (-), together with eight known depsidones (-) were isolated from the endophytic fungus, detached from stems of Thai rice. Their structures were determined by extensive spectroscopic methods. Mollicellins X, H, and F (, and ) showed potent cytotoxicity against the human oral epidermoid carcinoma (KB) cell line, and mollicellin F () also showed a potent cytotoxicity against the human hepatocellular carcinoma (HepG2) cell line. Besides, mollicellin B () exhibited cytotoxicity against the colorectal adenocarcinoma (HT-29) cell line. Moreover, most of the isolated depsidones displayed potent antibacterial activity against Gram-positive bacteria, and , and several of them showed moderate activity against Methicillin-resistant (MRSA) and clinical isolates of In addition, a few of them also showed moderate activity against a Gram-negative bacteria

摘要

从泰国大米的茎部分离得到的内生真菌中分离得到了四个新的去甲二萜酮，即莫利塞林 V-Y(-)，以及八个已知的去甲二萜酮(-)。通过广泛的光谱方法确定了它们的结构。莫利塞林 X、H 和 F（、和）对人口腔表皮样癌细胞（KB）系具有很强的细胞毒性，而莫利塞林 F（）对人肝癌细胞（HepG2）系也具有很强的细胞毒性。此外，莫利塞林 B（）对结肠直肠腺癌（HT-29）系具有细胞毒性。此外，大多数分离出的去甲二萜酮对革兰氏阳性菌表现出很强的抗菌活性，和，其中一些对耐甲氧西林金黄色葡萄球菌（MRSA）和临床分离株也表现出中等活性。此外，其中一些对革兰氏阴性菌也表现出中等活性。