Blatt J, Wenger S, Stitely S, Lee P A
Eur J Pediatr. 1987 May;146(3):257-60. doi: 10.1007/BF00716469.
To determine whether human growth hormone (HGH) can cause proliferation of human leukemic lymphoblasts, we studied colony formation in semi-solid medium of MOLT 4, a cell line derived from an adolescent with acute lymphoblastic leukemia (ALL). Although exposure to single doses of HGH in supraphysiologic concentrations resulted in almost two-fold increases in number of colonies compared with control samples, physiologic concentrations had no effect. Similarly, physiologic concentrations of HGH had no effect on thymidine incorporation in short-term cultures of fresh lymphoblasts from children with ALL. In addition, total white blood cell and differential counts in 14 children with isolated growth hormone deficiency were reviewed pre- and post-treatment with HGH. In no case was there evidence of in vivo lymphocytosis or blastogenesis.
为了确定人类生长激素（HGH）是否会导致人类白血病淋巴母细胞增殖，我们研究了MOLT 4在半固体培养基中的集落形成情况，MOLT 4是一种源自一名患有急性淋巴细胞白血病（ALL）的青少年的细胞系。尽管与对照样本相比，暴露于超生理浓度的单剂量HGH会使集落数量增加近两倍，但生理浓度却没有影响。同样，生理浓度的HGH对来自ALL患儿的新鲜淋巴母细胞短期培养中的胸苷掺入也没有影响。此外，对14例孤立性生长激素缺乏症患儿在接受HGH治疗前后的全血细胞计数和分类计数进行了回顾。在任何情况下都没有体内淋巴细胞增多或母细胞生成的证据。
