Wang Dong, Ruan Zhen, Zhang Rongchao, Wang Xuejing, Wang Ruihui, Tang Zhishu
Medical Research and Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, China.
Shaanxi University of Chinese Medicine, Xianyang, China.
Front Pharmacol. 2021 Oct 22;12:691742. doi: 10.3389/fphar.2021.691742. eCollection 2021.
Earthworm, also called dilong (Chinese language), has been used as a traditional Chinese medicine for thousands of years. Recently, some scientists believe that earthworm extracts (EE) can promote wound healing. However, its effectiveness remains controversial. We conducted a meta-analysis to evaluate the effect of EE on wound healing based on the healing rate. We comprehensively reviewed literature that mentioned EE for wound healing in the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP database for Chinese Technical Periodicals, and WanFang database that have been published until January 2021. We computed weighted mean difference (WMD) for analysis with RevMan 5.3 software in animal and human models groups. Two researchers independently selected studies and evaluated the risk of bias with the Cochrane Collaboration tool. The quality of the evidence was assessed with the Cochrane risk of bias tool. This study is registered on PROSPERO (CRD42020168400). From 2,486 articles, we selected 16 studies for analysis. EE treatment was associated with improvements in wound healing performance based on wound healing rate (mouse model: weighted mean difference (WMD) = 3.55, 95% confidence interval (CI): 2.34-4.77, < 0.00001; rat model: WMD = 17.29, 95% CI: 5.75-28.82, = 0.003; rabbit model: WMD = 19.29, 95% CI: 9.95-28.64, < 0.0001). Clinical studies also confirmed that EE could reduce healing time in hospital (WMD = -8.94, 95% CI: -17.75 to -0.14, = 0.05). The results of this meta-analysis demonstrated the efficacy of EE on wound healing process. As a corollary, EE can be a useful natural product for wound healing drug development. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=168400, identifier CRD42020168400.
蚯蚓，又称地龙（中文名称），作为传统中药已使用了数千年。最近，一些科学家认为蚯蚓提取物（EE）可以促进伤口愈合。然而，其有效性仍存在争议。我们进行了一项荟萃分析，以基于愈合率评估EE对伤口愈合的影响。我们全面检索了截至2021年1月在PubMed、Cochrane图书馆、Embase、科学网、中国知网、维普中文科技期刊数据库和万方数据库中提及EE用于伤口愈合的文献。我们使用RevMan 5.3软件计算动物模型组和人类模型组分析的加权平均差（WMD）。两名研究人员独立选择研究，并使用Cochrane协作工具评估偏倚风险。证据质量使用Cochrane偏倚风险工具进行评估。本研究已在PROSPERO（CRD42020168400）注册。从2486篇文章中，我们选择了16项研究进行分析。基于伤口愈合率，EE治疗与伤口愈合性能的改善相关（小鼠模型：加权平均差（WMD）=3.55，95%置信区间（CI）：2.34 - 4.77，P<0.00001；大鼠模型：WMD = 17.29，95%CI：5.75 - 28.82，P = 0.003；兔模型：WMD = 19.29，95%CI：9.95 - 28.64，P < 0.0001）。临床研究也证实EE可以缩短住院愈合时间（WMD = -8.94，95%CI：-17.75至-0.14，P = 0.05）。这项荟萃分析的结果证明了EE在伤口愈合过程中的有效性。因此，EE可以成为用于伤口愈合药物开发的有用天然产物。https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=168400，标识符CRD42020168400。
