RNA甲基化在调控干细胞命运和功能中的作用——聚焦于N6-甲基腺嘌呤
The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on mA.
作者信息
Sun Weiwei, Zhang Bin, Bie Qingli, Ma Na, Liu Na, Shao Zewei
机构信息
Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, China.
Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
出版信息
Stem Cells Int. 2021 Oct 28;2021:8874360. doi: 10.1155/2021/8874360. eCollection 2021.
The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases.
RNA甲基化在干细胞中的生物学作用已引起越来越多的关注。最近的研究表明，RNA甲基化在干细胞的自我更新、分化和致瘤性中起着关键作用。在本综述中，我们重点关注RNA甲基化修饰（包括N6-甲基腺苷、5-甲基胞嘧啶和尿苷酸化）在胚胎干细胞、成体干细胞、诱导多能干细胞和癌症干细胞中的生物学作用，以便为癌症或其他复杂疾病的潜在创新治疗提供新的见解。
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